ArticleJournal of bone and mineral metabolism2011
Simulated evolution of the vertebral body based on basic multicellular unit activities.
Article in Journal of bone and mineral metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Mechanoregulated trabecular bone adaptation: Progress report onBiomaterials and biosystems · 2022Review
- Computational modelling of bone augmentation in the spine.Journal of orthopaedic translation · 2015Review
- A comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast-like cells.Biomedical engineering online · 2015Article
- Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation.PloS one · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A numerical model based on the theory of bone remodeling is proposed to predict the evolution of trabecular bone architecture within the vertebral body and to investigate the process of degeneration in vertebral bone. In this study, particular attention is paid on the description of microstructure changes during the aging process. To take into account the effect of basic multicellular units (BMUs), a set of computational algorithms has been developed. It is assumed that BMU activation probability depends on the state of damaged bone tissue (damage accumulation, ω), which is evaluated according to previous research concerning bone fatigue damage. Combining these algorithms with the finite-element method (FEM), the microstructure of vertebral bone has been predicted for up to 8 simulated years. Moreover, biomechanical material properties have been monitored to investigate the changes of vertebral bone with age. This study shows that the simulation based on BMU activities has the potential to define and predict the morphological evolution of the vertebral body. It can be concluded that the novel algorithms incorporating the coupled effects of both adaptive remodeling and microdamage remodeling could be utilized to gain greater insight into the mechanism of bone loss in the elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.