ArticleMolecular biology reports2011
Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Preliminary study on the mechanism of OPN up-regulating PD-L1 to induce CD8 + T cell exhaustion in synovial sarcoma.BMC cancer · 2026Article
- SPP1 is a prognostic related biomarker and correlated with tumor-infiltrating immune cells in ovarian cancer.BMC cancer · 2022Article
- MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells.Cancer cell international · 2021Review
- Review
- Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro.International journal of molecular sciences · 2020Article
- Immunotherapy of hepatocellular carcinoma using chimeric antigen receptors and bispecific antibodies.Cancer letters · 2017Review
- NF‑κB inhibition is associated with OPN/MMP‑9 downregulation in cutaneous melanoma.Oncology reports · 2017Article
- A preliminary in vivo study of the effects of OPN on rat liver regeneration induced by partial hepatectomy.Molecular biology reports · 2016Article
- Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells.BMC cancer · 2016Article
- Management of hepatocellular carcinoma: Predictive value of immunohistochemical markers for postoperative survival.World journal of hepatology · 2015Review
- Article
- Glycosylation and liver cancer.Advances in cancer research · 2015Review
- Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients.Journal of cancer research and clinical oncology · 2014Article
- OPN and αvβ3 expression are predictors of disease severity and worse prognosis in hepatocellular carcinoma.PloS one · 2014Article
- Effect of thalidomide on the proliferation of hepatoma cells assessed by osteopontin levels in nude mice.Experimental and therapeutic medicine · 2013Article
- NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.Gut · 2012Article
- Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers.World journal of gastroenterology · 2012Review
- Pre- and post-translational regulation of osteopontin in cancer.Journal of cell communication and signaling · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopontin (OPN) plays an important role in metastasis and relapse of human cancer. However, the whole story of OPN relating to cancer has been far from clear untill now. To investigate the expression of OPN in hepatocellular carcinoma (HCC) and its relationships with recurrence and metastasis of HCC, normal and malignant liver tissues from patients with HCC were analyzed using immunohistochemical staining. OPN expression was inhibited by small interfering RNA (siRNA) in HCC cells lines, and then colony formation and matrigel invasion were examined. The results showed that expression of OPN was associated with metastasis of HCC with a positive rate of OPN in the tissue of HCC (70.00%), which was highly more obvious than those in paracarcinoma tissue and normal liver tissue (P < 0.01). In HCC cell lines, OPN depletion could reduce formed colony and metastasizing numbers in vitro. In conclusion, Expression of OPN in the tissue of HCC is related to metastasis or metastases. Specific siRNA could decrease expressions of OPN at both mRNA and protein levels, and abates the invasiveness of hepatocellular carcinoma cells, suggesting that OPN might be a promising agent for treatment of metastasis and recurrence of HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.