ArticleCancer causes & control : CCC2011
Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study.
Article in Cancer causes & control : CCC, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Pooled it
- Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis.PloS one · 2012Pooled it
- Prospective study of DNA methylation at LINE-1 and Alu in peripheral blood and the risk of prostate cancer.The Prostate · 2015Trial
- Methylation of LINE-1 and Alu repetitive sequence in keloid.Scientific reports · 2025Article
- Cohort Network: A Knowledge Graph toward Data Dissemination and Knowledge-Driven Discovery for Cohort Studies.Environmental science & technology · 2023Article
- Folic Acid Supplementation Promotes Hypomethylation in Both the Inflamed Colonic Mucosa and Colitis-Associated Dysplasia.Cancers · 2023Article
- Quadrato Motor Training (QMT) is associated with DNA methylation changes at DNA repeats: A pilot study.PloS one · 2023Article
- DNA methylation topology differentiates between normal and malignant in cell models, resected human tissues, and exfoliated sputum cells of lung epithelium.Frontiers in oncology · 2022Article
- Global DNA (LINE-1) methylation is associated with lead exposure and certain job tasks performed by electronic waste workers.International archives of occupational and environmental health · 2021Article
- Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging.Frontiers in genetics · 2019Review
- Repetitive Element DNA Methylation is Associated with Menopausal Age.Aging and disease · 2018Article
- Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2017Review
- Disease relevant modifications of the methylome and transcriptome by particulate matter (PMEpigenetics · 2017Article
- Methylation of subtelomeric repeat D4Z4 in peripheral blood leukocytes is associated with biochemical recurrence in localized prostate cancer patients.Carcinogenesis · 2017Article
- Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer.Biological procedures online · 2017Review
- Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation.Aging cell · 2016Article
- Prospective changes in global DNA methylation and cancer incidence and mortality.British journal of cancer · 2016Article
- Blood Epigenetic Age may Predict Cancer Incidence and Mortality.EBioMedicine · 2016Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundGlobal genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements. Case-control studies have associated blood leukocyte DNA hypomethylation with several cancers. Because samples in case-control studies are collected after disease development, whether DNA hypomethylation is causal or just associated with cancer development is still unclear.
methodsIn 722 elderly subjects from the Normative Aging Study cohort, we examined whether DNA methylation in repetitive elements (Alu, LINE-1) was associated with cancer incidence (30 new cases, median follow-up: 89 months), prevalence (205 baseline cases), and mortality (28 deaths, median follow-up: 85 months). DNA methylation was measured by bisulfite pyrosequencing.
resultsIndividuals with low LINE-1 methylation (<median) had a 3.0-fold (95%CI 1.3-6.9) increased incidence of all cancers combined. LINE-1 and Alu methylation were not significantly associated with cancer prevalence at baseline (all cancers combined). However, individuals with low LINE-1 methylation (<median) had a 3.2-fold (95% CI 1.4-7.5) higher prevalence of lung cancer. Individuals with low LINE-1 or Alu methylation (<median) had increased cancer mortality (HR = 3.2, 95%CI 1.3-7.9 for LINE-1; HR = 2.5, 95%CI 1.1-5.8 for Alu).
conclusionThese findings suggest that individuals with lower repetitive element methylation are at high risk of developing and dying from cancer.
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