Trial reportHernia : the journal of hernias and abdominal wall surgery2011
Preemptive analgesia with midazolam and diclofenac for hernia repair pain.
Trial report in Hernia : the journal of hernias and abdominal wall surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Observational Study in Open Inguinal Hernia Repair
Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery
Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Modulating Influence of State Anxiety on the Effect of Midazolam on Postsurgical Pain.Journal of clinical medicine · 2023Article
- Effects of Premedication on Heart Rate Variability at Induction of Anaesthesia: Comparison between Midazolam and Hydroxyzine.Turkish journal of anaesthesiology and reanimation · 2018Article
- The impact of diclofenac and ibuprofen on biofilm formation on the surface of polypropylene mesh.Hernia : the journal of hernias and abdominal wall surgery · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to compare the preemptive effects of systemic midazolam and diclofenac on postoperative analgesia when used before surgical incision.
methodsNinety patients, aged 35-65 years, scheduled for hernia repair surgery were included in the study. Forty five patients in the midazolam group (group M + D) received 0.05 mg/kg midazolam and 1.5 mg/kg diclofenac, 15 min before surgical incision; 45 patients in the diclofenac group (group D) received diclofenac without midazolam, 15 min before surgical incision. Postoperative pain (Verbal Rating Scale-6) score and first analgesic requirement were noted. Sedation levels were evaluated with Observer's Assessment of Alertness/Sedation (OAA/S) score. Adverse effects during and after the operation were also recorded.
resultsGroup M + D had a significantly lower proportion of patients who exhibited postoperative pain than group D (11.1% vs. 37.7%, respectively; P < 0.05). The VRS-6 score in group M + D was 1.4 (range 0-4), whereas the corresponding score in group D was 2.4 (range 1-6). Mean (OAA/S) score in group M + D was lower than in the group D (1.5 ± 0.3 vs. 3.3 ± 0.4, respectively; P < 0.05). Duration of sedation in group M + D was significantly longer than the corresponding mean for group D (22.5 ± 6.4 vs. 12.1 ± 3.3 min, respectively; P < 0.01). The first postoperative analgesic request after surgery was 120 min in group M + D and 60 min in group D (P < 0.05).
conclusionMidazolam enhances the postoperative analgesic effects of diclofenac when used before the onset of noxious stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.