ArticleJournal of skin cancer2011
Two distinct pathways to development of squamous cell carcinoma of the vulva.
Article in Journal of skin cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- Differentiated vulvar intraepithelial neoplasia long-term follow up and prognostic factors: An analysis of a large historical cohort.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Necrotizing fasciitis arising from squamous cell carcinoma of the vulva.Dermatology reports · 2022Article
- Early Diagnostics of Vulvar Intraepithelial Neoplasia.Cancers · 2022Review
- Prevalence and type distribution of human papillomavirus infections in Danish patients diagnosed with vulvar squamous cell tumors and precursors.Gynecologic oncology reports · 2021Article
- Article
- Study on collagen parameters in vulvar cancer and preneoplastic lesions by Second Harmonic Generation microscopy.Scientific reports · 2020Article
- Cerebral metastasis in recurrent squamous cell carcinoma of the vulva: case report and review of the literature.Archives of gynecology and obstetrics · 2020Review
- Vulvar Lichen Sclerosus: Current Perspectives.International journal of women's health · 2020Review
- A Case of Stage I Vulvar Squamous Cell Carcinoma with Early Relapse and Rapid Disease Progression.Case reports in oncological medicine · 2019Article
- Vulvar cancer in Ethiopia: A cohort study on the characteristics and survival of 86 patients.Medicine · 2018Observational
- The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia.Biomedicines · 2018Review
- Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer.Oncology letters · 2018Article
- Survival and failure types after radiation therapy of vulvar cancer.Clinical and translational radiation oncology · 2017Article
- Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases.Virchows Archiv : an international journal of pathology · 2017Article
- Factors Affecting Gynecologic and Sexual Assessment in Older Women: A Lesson for Primary Care Providers.Healthcare (Basel, Switzerland) · 2015Article
- Article
- Oncogenic viral prevalence in invasive vulvar cancer specimens from human immunodeficiency virus-positive and -negative women in Botswana.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2014Article
- Cell cycle suppressor proteins are not related to HPV status or clinical outcome in patients with vulvar carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Spindle cell morphology is related to poor prognosis in vulvar squamous cell carcinoma.British journal of cancer · 2013Article
- Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma.World journal of urology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population. Two different pathways for vulvar SCC have been put forth. The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV). Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of p14(ARF) and p16(INK4A). This lesion subsequently forms a warty- or basaloid-type SCC. The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva. The second pathway is HPV-independent. Keratinizing SCC develops within a background of lichen sclerosus (LS) through a differentiated VIN. It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI). Further clinical and basic research is still required to understand and prevent vulvar SCC. Capsule. Two pathway for pathogenesis of squamous cell carcinoma of the value are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.