ArticleInternational journal of inflammation2010
Microbial sensing by the intestinal epithelium in the pathogenesis of inflammatory bowel disease.
Article in International journal of inflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- The evidence for fungus in Crohn's disease pathogenesis.Clinical journal of gastroenterology · 2018Review
- The Impact of Cold Spells on the Incidence of Infectious Gastroenteritis and Relapse Rates of Inflammatory Bowel Disease: A Retrospective Controlled Observational Study.Inflammatory intestinal diseases · 2017Article
- Dysregulation of microRNA biogenesis in the small intestine after ethanol and burn injury.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Microbiome-Linked Crosstalk in the Gastrointestinal Exposome towards Host Health and Disease.Pediatric gastroenterology, hepatology & nutrition · 2016Review
- Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis.Cell death and differentiation · 2015Article
- What Role Does Mycobacterium avium subsp. paratuberculosis Play in Crohn's Disease?Current infectious disease reports · 2015Article
- Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice.Gut pathogens · 2013Article
- Dysbiosis in the pathogenesis of pediatric inflammatory bowel diseases.International journal of inflammation · 2012Article
- Caspase deficiency alters the murine gut microbiome.Cell death & disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent years have raised evidence that the intestinal microbiota plays a crucial role in the pathogenesis of chronic inflammatory bowels diseases. This evidence comes from several observations. First, animals raised under germ-free conditions do not develop intestinal inflammation in several different model systems. Second, antibiotics are able to modulate the course of experimental colitis. Third, genetic polymorphisms in a variety of genes of the innate immune system have been associated with chronic intestinal inflammatory diseases. Dysfunction of these molecules results in an inappropriate response to bacterial and antigenic stimulation of the innate immune system in the gastrointestinal tract. Variants of pattern recognition receptors such as NOD2 or TLRs by which commensal and pathogenic bacteria can be detected have been shown to be involved in the pathogenesis of IBD. But not only pathways of microbial detection but also intracellular ways of bacterial processing such as autophagosome function are associated with the risk to develop Crohn's disease. Thus, the "environment concept" and the "genetic concept" of inflammatory bowel disease pathophysiology are converging via the intestinal microbiota and the recognition mechanisms for an invasion of members of the microbiota into the mucosa.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.