ArticleInternational journal of vascular medicine2010
Caffeine's Vascular Mechanisms of Action.
Article in International journal of vascular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05295784 (Pharmacokinetics), which is not on this map. Cited by 103 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Who cites it
103 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effects of Nutritional Supplements on Explosive Lower Limb Performance in Volleyball Players: A Systematic Review and Network Meta-Analysis.Nutrients · 2025Pooled it
- Physiological influences on neurovascular coupling: A systematic review of multimodal imaging approaches and recommendations for future study designs.Experimental physiology · 2025Pooled it
- Association between caffeine intake and erectile dysfunction: a meta-analysis of cohort studies.Journal of health, population, and nutrition · 2024Pooled it
- Caffeine intake enhances bowel recovery after colorectal surgery: a meta-analysis of randomized and non-randomized studies.Updates in surgery · 2024Pooled it
- The association between antenatal coffee consumption and preeclampsia: a systematic review and meta-analysis.Environmental health and preventive medicine · 2024Pooled it
- Factors Associated with the Prevalence and Severity of Menstrual-Related Symptoms: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effect of Postoperative Coffee Consumption on Postoperative Ileus after Abdominal Surgery: An Updated Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- The effects of caffeine in adults with neurogenic orthostatic hypotension: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Pooled it
- Both acute and chronic caffeine consumption affect cardiovascular responses to total sleep deprivation.Frontiers in cardiovascular medicine · 2026Trial
- Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation.Experimental physiology · 2025Trial
- Effect of isolated and combined ingestion of caffeine and citrulline malate on resistance exercise and jumping performance: a randomized double-blind placebo-controlled crossover study.European journal of nutrition · 2023Trial
- Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension.Nutrients · 2022Trial
- Stored RBC metabolism as a function of caffeine levels.Transfusion · 2020Trial
- Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test.British journal of clinical pharmacology · 2020Trial
- Cardiac autonomic activity during sleep deprivation with and without caffeine administration.Physiology & behavior · 2019Trial
- Trial
- Pre-Exercise Caffeine as a Modulator of Exercise-Induced Acute Cardiometabolic Responses: A Narrative Review.Metabolites · 2026Review
- Caffeine and Headache: Exploring the Multifaceted Relationship.Brain and behavior · 2026Review
- Caffeine before cesarean delivery: a novel preventive strategy against spinal hypotension, a double blind placebo-controlled trial.Journal of anesthesia, analgesia and critical care · 2026Article
- Effects of caffeinated chewing gum on prolonged repeated-sprint performance in normobaric hypoxia.Frontiers in nutrition · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. In vascular smooth muscle cells its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation. In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction. In this paper the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.