ArticleJournal of biomedicine & biotechnology2011
Identification of urinary biomarkers of colon inflammation in IL10-/- mice using Short-Column LCMS metabolomics.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis.International journal of molecular sciences · 2023Pooled it
- Translational Potential of Metabolomics on Animal Models of Inflammatory Bowel Disease-A Systematic Critical Review.International journal of molecular sciences · 2020Pooled it
- Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation.Frontiers in microbiology · 2026Article
- Comparison of muscle metabolomics between two Chinese horse breeds.Frontiers in veterinary science · 2023Article
- Untargeted Metabolomics Reveals the Effect of Selective Breeding on the Quality of Chicken Meat.Metabolites · 2022Article
- Urinary metabolites as noninvasive biomarkers of gastrointestinal diseases: A clinical review.World journal of gastrointestinal oncology · 2016Review
- PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity.Toxicology · 2013Article
- Metabolomics: is it useful for inflammatory bowel diseases?Current opinion in gastroenterology · 2013Review
- Clinical metabolomics paves the way towards future healthcare strategies.British journal of clinical pharmacology · 2013Review
- Indoleamine 2,3 dioxygenase in intestinal disease.Current opinion in gastroenterology · 2013Review
- Article
- Changes in bowel microbiota induced by feeding weanlings resistant starch stimulate transcriptomic and physiological responses.Applied and environmental microbiology · 2012Article
- Biomarkers in inflammatory bowel disease: current practices and recent advances.Translational research : the journal of laboratory and clinical medicine · 2012Review
- Metabolomic applications to decipher gut microbial metabolic influence in health and disease.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interleukin-10-deficient (IL10(-/-)) mouse develops colon inflammation in response to normal intestinal microflora and has been used as a model of Crohn's disease. Short-Column LCMS metabolite profiling of urine from IL10(-/-) and wild-type (WT) mice was used, in two independent experiments, to identify mass spectral ions differing in intensity between these two genotypes. Three differential metabolites were identified as xanthurenic acid and as the glucuronides of xanthurenic acid and of α-CEHC (2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman). The significance of several differential metabolites as potential biomarkers of colon inflammation was evaluated in an experiment which compared metabolite concentrations in IL10(-/-) and WT mice housed, either under conventional conditions and dosed with intestinal microflora, or maintained under specific pathogen-free (SPF) conditions. Concentrations of xanthurenic acid, α-CEHC glucuronide, and an unidentified metabolite m/z 495(-)/497(+) were associated with the degree of inflammation in IL10(-/-) mice and may prove useful as biomarkers of colon inflammation.
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