ArticleJournal of nutrition and metabolism2010
Interaction among Skeletal Muscle Metabolic Energy Systems during Intense Exercise.
Article in Journal of nutrition and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
164 citing papers in PubMed, 9 syntheses or guidelines pooled it, 372 citations in OpenAlex.
- Effects of mental fatigue on lower-limb explosive power and anaerobic capacity: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Evidence-Based Supplementation Strategies for Wrestlers: A Systematic Review.Current nutrition reports · 2025Pooled it
- Effects of citrulline on endurance performance in young healthy adults: a systematic review and meta-analysis.Journal of the International Society of Sports Nutrition · 2023Pooled it
- The Effect of Carbohydrate Intake on Strength and Resistance Training Performance: A Systematic Review.Nutrients · 2022Pooled it
- The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The Effect of Dietary Supplements on Endurance Exercise Performance and Core Temperature in Hot Environments: A Meta-analysis and Meta-regression.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.PloS one · 2021Pooled it
- Effects of Creatine Supplementation on Athletic Performance in Soccer Players: A Systematic Review and Meta-Analysis.Nutrients · 2019Pooled it
- The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Efficacy and Safety of Enzyme-Derived Deer Velvet Extract Supplementation on Adults with Chronic Fatigue: a Randomized, Placebo-Controlled, Double-Blind Trial.Journal of microbiology and biotechnology · 2026Trial
- Trial
- Training Parameters and Adaptations That Mediate Walking Capacity Gains from High-Intensity Gait Training Poststroke.Medicine and science in sports and exercise · 2025Trial
- Acute Effects of Traditional Versus Cluster Set Upper Body Resistance Training on Heart Rate Variability and Blood Pressure in Trained Men.European journal of sport science · 2025Trial
- Cardiopulmonary and Urine Electrolyte Changes in Healthy Males Exposed to Two Distinct Anaerobic Exercises.Cardiovascular & hematological disorders drug targets · 2025Trial
- Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of aNutrients · 2023Trial
- A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial.International journal of medical sciences · 2023Trial
- The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial.Journal of the International Society of Sports Nutrition · 2021Trial
- Trial
- The Effects of Long-Term Magnesium Creatine Chelate Supplementation on Repeated Sprint Ability (RAST) in Elite Soccer Players.Nutrients · 2020Trial
- The effect of prior upper body exercise on subsequent wingate performance.BioMed research international · 2014Trial
104 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-intensity exercise can result in up to a 1,000-fold increase in the rate of ATP demand compared to that at rest (Newsholme et al., 1983). To sustain muscle contraction, ATP needs to be regenerated at a rate complementary to ATP demand. Three energy systems function to replenish ATP in muscle: (1) Phosphagen, (2) Glycolytic, and (3) Mitochondrial Respiration. The three systems differ in the substrates used, products, maximal rate of ATP regeneration, capacity of ATP regeneration, and their associated contributions to fatigue. In this exercise context, fatigue is best defined as a decreasing force production during muscle contraction despite constant or increasing effort. The replenishment of ATP during intense exercise is the result of a coordinated metabolic response in which all energy systems contribute to different degrees based on an interaction between the intensity and duration of the exercise, and consequently the proportional contribution of the different skeletal muscle motor units. Such relative contributions also determine to a large extent the involvement of specific metabolic and central nervous system events that contribute to fatigue. The purpose of this paper is to provide a contemporary explanation of the muscle metabolic response to different exercise intensities and durations, with emphasis given to recent improvements in understanding and research methodology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.