ArticlePloS one2010
Genetic variation in the complete MgPa operon and its repetitive chromosomal elements in clinical strains of Mycoplasma genitalium.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Novel features ofMicrobial genomics · 2026Article
- Detection of human IgG antibodies againstJournal of clinical microbiology · 2025Article
- Diversity of Mycoplasma genitalium strains in Australia: relationship with sexual networks and antimicrobial resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- JMM Profile:Journal of medical microbiology · 2025Review
- Pathogenicity and virulence ofVirulence · 2022Review
- Molecular Tools for TypingFrontiers in microbiology · 2022Review
- Alternative conformation of the C-domain of the P140 protein from Mycoplasma genitalium.Acta crystallographica. Section F, Structural biology communications · 2020Article
- Single-Locus-Sequence-Based Typing of theJournal of clinical microbiology · 2020Article
- Article
- Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.Nature communications · 2018Article
- Risk factors forSexually transmitted infections · 2018Article
- Mycoplasma genitalium Nonadherent Phase Variants Arise by Multiple Mechanisms and Escape Antibody-Dependent Growth Inhibition.Infection and immunity · 2018Article
- Prevalence ofGerms · 2018Article
- Mycoplasma genitalium: whole genome sequence analysis, recombination and population structure.BMC genomics · 2017Article
- The Unique Microbiology and Molecular Pathogenesis of Mycoplasma genitalium.The Journal of infectious diseases · 2017Review
- Inter- and intra-strain variability of tandem repeats in Mycoplasma pneumoniae based on next-generation sequencing data.Future microbiology · 2017Article
- Article
- Bacterial Load in Daily Urine Samples of Patients Infected withInfectious diseases in obstetrics and gynecology · 2016Article
- Kinetics of Genetic Variation of the Mycoplasma genitalium MG192 Gene in Experimentally Infected Chimpanzees.Infection and immunity · 2015Article
- Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Mycoplasma genitalium has been increasingly recognized as an important microbe not only because of its significant association with human genital tract diseases but also because of its utility as a model for studying the minimum set of genes necessary to sustain life. Despite its small genome, 4.7% of the total genome sequence is devoted to making the MgPa adhesin operon and its nine chromosomal repetitive elements (termed MgPars). The MgPa operon, along with 9 MgPars, is believed to play an important role in pathogenesis of M. genitalium infection and has also served as the main target for development of diagnostic tools. However, genetic variation in the complete MgPa operon and MgPars among clinical strains of M. genitalium has not been addressed. In this study we examined the genetic variation in the complete MgPa operon (approximately 8.5 kb) and full or partial MgPar sequences (0.4-2.6 kb) in 15 geographically diverse strains of M. genitalium. Extensive variation was present in four repeat regions of the MgPa operon (with homology to MgPars) among and within strains while the non-repeat regions (without homology to MgPars) showed low-level variation among strains and no variation within strains. MgPars showed significant variation among strains but were highly homogeneous within strains, supporting gene conversion as the likely recombination mechanism. When applying our sequence data to evaluate published MgPa operon-based diagnostic PCR assays and genotyping systems, we found that 11 of 19 primers contain up to 19 variable nucleotides and that the target for one of two typing systems is located in a hypervariable repeat region, suggesting the likelihood of false results with some of these assays. This study not only provides new insights into the role of the MgPa operon in the pathogenesis of M. genitalium infection but has important implications for the development of diagnostic tools.
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