ArticleCritical care medicine2011
A porcine model for initial surge mechanical ventilator assessment and evaluation of two limited-function ventilators.
Article in Critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Induction of subject-ventilator asynchrony by variation of respiratory parameters in a lung injury model in pigs.Respiratory research · 2024Article
- Assessment of hemodynamics, blood gases, and lung histopathology of healthy Pig model on two different mechanical ventilators.Heliyon · 2022Article
- Article
- A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures.Physiological reports · 2021Article
- Increasing ventilator surge capacity in COVID 19 pandemic: design, manufacture and in vitro-in vivo testing in anaesthetized healthy pigs of a rapid prototyped mechanical ventilator.BMC research notes · 2020Article
- Emergency ventilator for COVID-19.PloS one · 2020Article
- Review
- DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.Trends in immunology · 2011Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo adapt an animal model of acute lung injury for use as a standard protocol for a screening initial evaluation of limited function, or "surge," ventilators for use in mass casualty scenarios.
designProspective, experimental animal study.
settingUniversity research laboratory. SUBJECTS: Twelve adult pigs.
interventionsTwelve spontaneously breathing pigs (six in each group) were subjected to acute lung injury/acute respiratory distress syndrome via pulmonary artery infusion of oleic acid. After development of respiratory failure, animals were mechanically ventilated with a limited-function ventilator (simplified automatic ventilator [SAVe] I or II; Automedx, Germantown, MD) for 1 hr or until the ventilator could not support the animal. The limited-function ventilator was then exchanged for a full-function ventilator (Servo 900C; Siemens-Elema, Solna, Sweden). MEASUREMENTS AND MAIN
resultsReliable and reproducible levels of acute lung injury/acute respiratory distress syndrome were induced. The SAVe I was unable to adequately oxygenate five animals with Pao2 (52.0±11.1 torr) compared to the Servo (106.0±25.6 torr; p=.002). The SAVe II was able to oxygenate and ventilate all six animals for 1 hr with no difference in Pao2 (141.8±169.3 torr) compared to the Servo (158.3±167.7 torr).
conclusionsWe describe a novel in vivo model of acute lung injury/acute respiratory distress syndrome that can be used to initially screen limited-function ventilators considered for mass respiratory failure stockpiles and that is intended to be combined with additional studies to definitively assess appropriateness for mass respiratory failure. Specifically, during this study we demonstrate that the SAVe I ventilator is unable to provide sufficient gas exchange, whereas the SAVe II, with several more functions, was able to support the same level of hypoxemic respiratory failure secondary to acute lung injury/acute respiratory distress syndrome for 1 hr.
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