ArticleProceedings of the National Academy of Sciences of the United States of America2011
Unitary response of mouse olfactory receptor neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- A visual opsin from jellyfish enables precise temporal control of G protein signalling.Nature communications · 2023Article
- Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cyclic-nucleotide-gated cation current and Ca2+-activated Cl current elicited by odorant in vertebrate olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- Ultrasensitive detection of amines by a trace amine-associated receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.Neural development · 2012Article
- Relationship between amino acid properties and functional parameters in olfactory receptors and discrimination of mutants with enhanced specificity.BMC bioinformatics · 2012Article
- Mitochondrial Ca(2+) mobilization is a key element in olfactory signaling.Nature neuroscience · 2012Article
- Functional and evolutionary aspects of chemoreceptors.Frontiers in cellular neuroscience · 2012Article
- Regulation and function of axon guidance and adhesion molecules during olfactory map formation.Journal of cellular biochemistry · 2011Review
- Perspectives on: information and coding in mammalian sensory physiology: response kinetics of olfactory receptor neurons and the implications in olfactory coding.The Journal of general physiology · 2011Article
- Detection and avoidance of a carnivore odor by prey.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The sense of smell begins with odorant molecules binding to membrane receptors on the cilia of olfactory receptor neurons (ORNs), thereby activating a G protein, G(olf), and the downstream effector enzyme, an adenylyl cyclase (ACIII). Recently, we have found in amphibian ORNs that an odorant-binding event has a low probability of activating sensory transduction at all; even when successful, the resulting unitary response apparently involves a single active Gα(olf)-ACIII molecular complex. This low amplification is in contrast to rod phototransduction in vision, the best-quantified G-protein signaling pathway, where each photoisomerized rhodopsin molecule is well known to produce substantial amplification by activating many G-protein, and hence effector-enzyme, molecules. We have now carried out similar experiments on mouse ORNs, which offer, additionally, the advantage of genetics. Indeed, we found the same low probability of transduction, based on the unitary olfactory response having a fairly constant amplitude and similar kinetics across different odorants and randomly encountered ORNs. Also, consistent with our picture, the unitary response of Gα(olf)(+/-) ORNs was similar to WT in amplitude, although their Gα(olf)-protein expression was only half of normal. Finally, from the action potential firing, we estimated that ≤19 odorant-binding events successfully triggering transduction in a WT mouse ORN will lead to signaling to the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.