ArticleJournal of cell science2011
Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Chemotactic TEG3 Cells' Guiding Platforms Based on PLA Fibers Functionalized With the SDF-1α/CXCL12 Chemokine for Neural Regeneration Therapy.Frontiers in bioengineering and biotechnology · 2021Article
- Why are olfactory ensheathing cell tumors so rare?Cancer cell international · 2019Review
- Intracellular calcium signal at the leading edge regulates mesodermal sheet migration during Xenopus gastrulation.Scientific reports · 2018Article
- ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM.Frontiers in cellular neuroscience · 2018Article
- Polarized Distribution of Active Myosin II Regulates Directional Migration of Cultured Olfactory Ensheathing Cells.Scientific reports · 2017Article
- Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system.PloS one · 2017Article
- Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain.Molecular neurobiology · 2017Article
- Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.The journal of physiological sciences : JPS · 2016Review
- Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.The Journal of cell biology · 2016Article
- Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation.eLife · 2015Article
- Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord.Cellular and molecular life sciences : CMLS · 2015Article
- Ca2+ signaling in cytoskeletal reorganization, cell migration, and cancer metastasis.BioMed research international · 2015Review
- R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse.PloS one · 2014Article
- Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Slits affect the timely migration of neural crest cells via Robo receptor.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Myelin-associated proteins block the migration of olfactory ensheathing cells: an in vitro study using single-cell tracking and traction force microscopy.Cellular and molecular life sciences : CMLS · 2012Article
- Intrinsic migratory properties of cultured Schwann cells based on single-cell migration assay.PloS one · 2012Article
- Designing Olfactory Ensheathing Cell Transplantation Therapies: Influence of Cell Microenvironment.Cell transplantationReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Olfactory ensheathing cells (OECs) migrate from the olfactory epithelium towards the olfactory bulb during development. However, the guidance mechanism for OEC migration remains a mystery. Here we show that migrating OECs expressed the receptor of the repulsive guidance factor Slit-2. A gradient of Slit-2 in front of cultured OECs first caused the collapse of the leading front, then the reversal of cell migration. These Slit-2 effects depended on the Ca(2+) release from internal stores through inositol (1,4,5)-triphosphate receptor channels. Interestingly, in response to Slit-2 stimulation, collapse of the leading front required the activation of the F-actin severing protein cofilin in a Ca(2+)-dependent manner, whereas the subsequent reversal of the soma migration depended on the reversal of RhoA activity across the cell. Finally, the Slit-2-induced repulsion of cell migration was fully mimicked by co-application of inhibitors of F-actin polymerization and RhoA kinase. Our findings revealed Slit-2 as a repulsive guidance factor for OEC migration and an unexpected link between Ca(2+) and cofilin signaling during Slit-2-triggered repulsion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.