ArticleThe Journal of cell biology2010
Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- The formation and function of intercellular bridges in male germlines.Communications biology · 2026Review
- Ring canals in the larval adipose of Drosophila buffer stress response.The Journal of cell biology · 2026Article
- The Roles of SHCBP1 in Cancer Hallmarks: Molecular Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2025Review
- The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy.Cell communication and signaling : CCS · 2024Article
- Review
- SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness.Frontiers in endocrinology · 2020Article
- EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression.Oncogene · 2019Article
- Review
- SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis.Journal of experimental & clinical cancer research : CR · 2017Article
- Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma.Oncotarget · 2016Article
- Controlling the switches: Rho GTPase regulation during animal cell mitosis.Cellular signalling · 2014Review
- SHCBP1 is required for midbody organization and cytokinesis completion.Cell cycle (Georgetown, Tex.) · 2014Article
- Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.PloS one · 2014Article
- Orbit/CLASP is required for germline cyst formation through its developmental control of fusomes and ring canals in Drosophila males.PloS one · 2013Article
- Article
- What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Cytokinesis microtubule organisers at a glance.Journal of cell science · 2012Review
- Cytokinesis in Drosophila male meiosis.Spermatogenesis · 2012Article
- ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.The EMBO journal · 2012Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Cytokinesis, the final step of cell division, usually ends with the abscission of the two daughter cells. In some tissues, however, daughter cells never completely separate and remain interconnected by intercellular bridges or ring canals. In this paper, we report the identification and analysis of a novel ring canal component, Nessun Dorma (Nesd), isolated as an evolutionarily conserved partner of the centralspindlin complex, a key regulator of cytokinesis. Nesd contains a pectin lyase-like domain found in proteins that bind to polysaccharides, and we present evidence that it has high affinity for β-galactosides in vitro. Moreover, nesd is an essential gene in Drosophila melanogaster, in which it is required for completion of cytokinesis during male meiosis and possibly in female germline cells. Our findings indicate that Nesd is a novel carbohydrate-binding protein that functions together with centralspindlin in late cytokinesis, thus highlighting the importance of glycosylation in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.