ArticleThe Journal of experimental medicine2011
Antiviral CD8+ T cell effector activities in situ are regulated by target cell type.
Article in The Journal of experimental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 135 citations in OpenAlex.
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- A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.Cell metabolism · 2022Article
- Anti-Interferon-γ Autoantibodies Impair T-Lymphocyte Responses in Patients withInfection and drug resistance · 2022Article
- Disease Tolerance during Viral-Bacterial Co-Infections.Viruses · 2021Review
- Long-term cigarette smoke exposure dysregulates pulmonary T cell response and IFN-γ protection to influenza virus in mouse.Respiratory research · 2021Article
- Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Review
- Tissue-resident CD4Science immunology · 2021Article
- Tissue-resident T cell-derived cytokines eliminate herpes simplex virus-2-infected cells.The Journal of clinical investigation · 2020Article
- Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies.Archives of virology · 2020Article
- Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance.PLoS pathogens · 2019Article
- PD-1Science immunology · 2019Article
- Targeting Peroxisome Proliferator-Activated Receptor-Gamma Decreases Host Mortality After Influenza Infection in Obese Mice.Viral immunology · 2019Article
- Review
- Absence of β6 Integrin Reduces Influenza Disease Severity in Highly Susceptible Obese Mice.Journal of virology · 2019Article
- Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.JCI insight · 2018Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cytotoxic T lymphocytes (CTLs) play a prominent role in the resolution of viral infections through their capacity both to mediate contact-dependent lysis of infected cells and to release soluble proinflammatory cytokines and chemokines. The factors controlling these antiviral effector activities in vivo at infection sites are ill defined. Using a mouse model of influenza infection, we observed that the expression of CTL effector activity in the infected lungs is dictated by the target cell type encountered. CD45(+) lung infiltrating inflammatory mononuclear cells, particularly CD11c(hi) dendritic cells, trigger both CTL cytotoxicity and release of inflammatory mediators, whereas CD45(-) influenza-infected respiratory epithelial cells stimulate only CTL cytotoxicity. CTL proinflammatory mediator release is modulated by co-stimulatory ligands (CD80 and CD86) expressed by the CD45(+) inflammatory cells. These findings suggest novel mechanisms of control of CTL effector activity and have potentially important implications for the control of excess pulmonary inflammation and immunopathology while preserving optimal viral clearance during respiratory virus infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.