ArticleActa biomaterialia2011
Thermoresponsive, in situ cross-linkable hydrogels based on N-isopropylacrylamide: fabrication, characterization and mesenchymal stem cell encapsulation.
Article in Acta biomaterialia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury.Frontiers in bioengineering and biotechnology · 2023Review
- Adjustable Thermo-Responsive, Cell-Adhesive Tissue Engineering Scaffolds for Cell Stimulation through Periodic Changes in Culture Temperature.International journal of molecular sciences · 2022Article
- Article
- Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications.Polymers · 2022Review
- Evaluating the physicochemical effects of conjugating peptides into thermogelling hydrogels for regenerative biomaterials applications.Regenerative biomaterials · 2021Article
- 3D bioprinting of tissue-specific osteoblasts and endothelial cells to model the human jawbone.Scientific reports · 2021Article
- Assessment of the embolization effect of temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels in the rabbit renal artery by CT perfusion and confirmed by macroscopic examination.Scientific reports · 2021Article
- Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application.Molecules (Basel, Switzerland) · 2019Review
- Thermogelling 3D Systems towards Stem Cell-Based Tissue Regeneration Therapies.Molecules (Basel, Switzerland) · 2018Review
- Injectable hydrogels for cartilage and bone tissue engineering.Bone research · 2017Review
- Effects of cellular parameters on the in vitro osteogenic potential of dual-gelling mesenchymal stem cell-laden hydrogels.Journal of biomaterials science. Polymer edition · 2016Article
- Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering.Biomaterials · 2016Article
- Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine.International journal of molecular sciences · 2015Review
- In vitro and in vivo evaluation of self-mineralization and biocompatibility of injectable, dual-gelling hydrogels for bone tissue engineering.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Synthesis and characterization of injectable, biodegradable, phosphate-containing, chemically cross-linkable, thermoresponsive macromers for bone tissue engineering.Biomacromolecules · 2014Article
- Mesenchymal stem cell and gelatin microparticle encapsulation in thermally and chemically gelling injectable hydrogels for tissue engineering.Journal of biomedical materials research. Part A · 2014Article
- Synthesis, physicochemical characterization, and cytocompatibility of bioresorbable, dual-gelling injectable hydrogels.Biomacromolecules · 2014Article
- Characterization of injectable hydrogels based on poly(N-isopropylacrylamide)-g-chondroitin sulfate with adhesive properties for nucleus pulposus tissue engineering.Journal of materials science. Materials in medicine · 2013Article
- Hydrogels in Healthcare: From Static to Dynamic Material Microenvironments.Acta materialia · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Hydrogels that solidify in response to a dual, physical and chemical, mechanism upon temperature increase were fabricated and characterized. The hydrogels were based on N-isopropylacrylamide, which renders them thermoresponsive, and contained covalently cross-linkable moieties in the macromers. The effects of the macromer end group, acrylate or methacrylate, and the fabrication conditions on the degradative and swelling properties of the hydrogels were investigated. The hydrogels exhibited higher swelling below their lower critical solution temperature (LCST). When immersed in cell culture medium at physiological temperature, which was above their LCST, hydrogels showed constant swelling and no degradation over 8 weeks, with the methacrylated hydrogels showing greater swelling than their acrylated analogs. In addition, hydrogels immersed in cell culture medium under the same conditions showed lower swelling compared with phosphate-buffered saline. The interplay between chemical cross-linking and thermally induced phase separation affected the swelling characteristics of the hydrogels in different media. Mesenchymal stem cells encapsulated in the hydrogels in vitro were viable over 3 weeks and markers of osteogenic differentiation were detected when the cells were cultured with osteogenic supplements. Hydrogel mineralization in the absence of cells was observed in cell culture medium with the addition of fetal bovine serum and β-glycerol phosphate. The results suggest that these hydrogels may be suitable as carriers for cell delivery in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.