ArticleThe Journal of infectious diseases2011
Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Asiatic Acid AttenuatesInternational journal of molecular sciences · 2026Article
- Epidemiological and clinicopathological findings in 15 fatal outbreaks of salmonellosis in dairy calves and virulence genes in the causative Salmonella enterica Typhimurium and Dublin strains.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Capsule-dependent impact of MAPK signalling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis.Fluids and barriers of the CNS · 2021Article
- Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration.Frontiers in neuroscience · 2021Article
- The Risk of Subsequent Deep Vein Thrombosis and Pulmonary Embolism in Patients with Nontyphoidal Salmonellosis: A Nationwide Cohort Study.International journal of environmental research and public health · 2020Article
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- Article
- Clinical and Microbiological Features of Salmonella Meningitis in a South African Population, 2003-2013.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Neisseria meningitidis elicits a pro-inflammatory response involving IκBζ in a human blood-cerebrospinal fluid barrier model.Journal of neuroinflammation · 2014Article
- Interactions of Salmonella with animals and plants.Frontiers in microbiology · 2014Review
- A novel C5a-derived immunobiotic peptide reduces Streptococcus agalactiae colonization through targeted bacterial killing.Antimicrobial agents and chemotherapy · 2013Article
- Concepts and mechanisms: crossing host barriers.Cold Spring Harbor perspectives in medicine · 2013Review
- Multiplicity of Salmonella entry mechanisms, a new paradigm for Salmonella pathogenesis.MicrobiologyOpen · 2012Article
- Defense at the border: the blood-brain barrier versus bacterial foreigners.Future microbiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the blood-brain barrier (BBB). Cellular invasion was dependent on host actin cytoskeleton rearrangements, while expression of a functional type III secretion system was not essential. In addition, Salmonella infection activated a proinflammatory immune response targeting neutrophil signaling and recruitment. Salmonella invasion and immune activation may represent a crucial step in the penetration of the BBB and development of Salmonella meningitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.