ArticleMolecular and cellular neurosciences2011
NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila.
Article in Molecular and cellular neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Calcineurin/NFAT signaling in the temporal integration of Ca²⁺ stress in neurodegeneration.Cell death discovery · 2026Review
- TheFrontiers in synaptic neuroscience · 2024Article
- Review
- A comparison of three different methods of eliciting rapid activity-dependent synaptic plasticity at the Drosophila NMJ.PloS one · 2021Article
- Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.Scientific reports · 2020Article
- Cholinergic Synaptic Homeostasis Is Tuned by an NFAT-Mediated α7 nAChR-KCell reports · 2020Article
- Review
- Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence.BMC genomics · 2017Article
- Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Activity-Dependent Synaptic Refinement: New Insights fromFrontiers in systems neuroscience · 2017Review
- Presynaptic CamKII regulates activity-dependent axon terminal growth.Molecular and cellular neurosciences · 2016Article
- Regulation of neurogenesis by calcium signaling.Cell calcium · 2016Review
- Mariner Transposons Contain a Silencer: Possible Role of the Polycomb Repressive Complex 2.PLoS genetics · 2016Article
- The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- The Drosophila transcription factor Adf-1 (nalyot) regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Behavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster.Brain research · 2012Article
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5 authors.
Funding
Abstract
The calcium-regulated transcription factor NFAT is emerging as a key regulator of neuronal development and plasticity but precise cellular consequences of NFAT function remain poorly understood. Here, we report that the single Drosophila NFAT homolog is widely expressed in the nervous system including motor neurons and unexpectedly controls neural excitability. Likely due to this effect on excitability, NFAT regulates overall larval locomotion and both chronic and acute forms of activity-dependent plasticity at the larval glutamatergic neuro-muscular synapse. Specifically, NFAT-dependent synaptic phenotypes include changes in the number of pre-synaptic boutons, stable modifications in synaptic microtubule architecture and pre-synaptic transmitter release, while no evidence is found for synaptic retraction or alterations in the level of the synaptic cell adhesion molecule FasII. We propose that NFAT regulates pre-synaptic development and constrains long-term plasticity by dampening neuronal excitability.
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