ArticleActa biomaterialia2011
Assessment of growth factor treatment on fibrochondrocyte and chondrocyte co-cultures for TMJ fibrocartilage engineering.
Article in Acta biomaterialia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Current clinical and translational challenges in temporomandibular joint reconstruction.Frontiers in bioengineering and biotechnology · 2025Review
- The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk.Dentistry journal · 2024Review
- Advances in 3D printing techniques for cartilage regeneration of temporomandibular joint disc and mandibular condyle.International journal of bioprinting · 2023Review
- Advances in Tissue Engineering of the Temporomandibular Joint Disc: An Overview of Current Status and Future Directions.International journal of dentistry · 2022Review
- Research progress on tissue engineering in repairing tempomandibular joint.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Article
- Engineering self-assembled neomenisci through combination of matrix augmentation and directional remodeling.Acta biomaterialia · 2020Article
- Tissue Engineering for the Temporomandibular Joint.Advanced healthcare materials · 2019Review
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
- Temporomandibular Joint Regenerative Medicine.International journal of molecular sciences · 2018Review
- The Yucatan Minipig Temporomandibular Joint Disc Structure-Function Relationships Support Its Suitability for Human Comparative Studies.Tissue engineering. Part C, Methods · 2017Article
- A review of in-vitro fibrocartilage tissue engineered therapies with a focus on the temporomandibular joint.Archives of oral biology · 2017Review
- Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders.Current osteoporosis reports · 2016Review
- Immortalization and characterization of mouse temporomandibular joint disc cell clones with capacity for multi-lineage differentiation.Osteoarthritis and cartilage · 2015Article
- Harnessing biomechanics to develop cartilage regeneration strategies.Journal of biomechanical engineering · 2015Review
- Critical seeding density improves the properties and translatability of self-assembling anatomically shaped knee menisci.Acta biomaterialia · 2015Article
- Combined use of chondroitinase-ABC, TGF-β1, and collagen crosslinking agent lysyl oxidase to engineer functional neotissues for fibrocartilage repair.Biomaterials · 2014Article
- Periodontal ligament mesenchymal stromal cells increase proliferation and glycosaminoglycans formation of temporomandibular joint derived fibrochondrocytes.BioMed research international · 2014Article
- Engineering functional anisotropy in fibrocartilage neotissues.Biomaterials · 2013Article
- Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc.Journal of the Royal Society, Interface · 2013Article
- A chondroitinase-ABC and TGF-β1 treatment regimen for enhancing the mechanical properties of tissue-engineered fibrocartilage.Acta biomaterialia · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Treatments for patients suffering from severe temporomandibular joint (TMJ) dysfunction are limited, motivating the development of strategies for tissue regeneration. In this study, co-cultures of fibrochondrocytes (FCs) and articular chondrocytes (ACs) were seeded in agarose wells, and supplemented with growth factors, to engineer tissue with biomechanical properties and extracellular matrix composition similar to native TMJ fibrocartilage. In the first phase, growth factors were applied alone and in combination, in the presence or absence of serum, while in the second phase, the best overall treatment was applied at intermittent dosing. Continuous treatment of AC/FC co-cultures with TGF-β1 in serum-free medium resulted in constructs with glycosaminoglycan/wet weight ratios (12.2%), instantaneous compressive moduli (790 kPa), relaxed compressive moduli (120 kPa) and Young's moduli (1.87 MPa) that overlap with native TMJ disc values. Among co-culture groups, TGF-β1 treatment increased collagen deposition ∼20%, compressive stiffness ∼130% and Young's modulus ∼170% relative to controls without growth factor. Serum supplementation, though generally detrimental to functional properties, was identified as a powerful mediator of FC construct morphology. Finally, both intermittent and continuous TGF-β1 treatment showed positive effects, though continuous treatment resulted in greater enhancement of construct functional properties. This work proposes a strategy for regeneration of TMJ fibrocartilage and its future application will be realized through translation of these findings to clinically viable cell sources.
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