ArticleHeart rhythm2011
Mapping of cardiac electrical activation with electromechanical wave imaging: an in silico-in vivo reciprocity study.
Article in Heart rhythm, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Assessing the atrial electromechanical coupling during atrial focal tachycardia, flutter, and fibrillation using electromechanical wave imaging in humans.Computers in biology and medicine · 2015Trial
- Simultaneous Widefield Voltage and Dye-Free Optical Mapping Quantifies Electromechanical Waves in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.ACS photonics · 2023Article
- Electromechanical Wave Imaging With Machine Learning for Automated Isochrone Generation.IEEE transactions on medical imaging · 2021Article
- Cardiac Resynchronization Therapy Response Assessment with Electromechanical Activation Mapping within 24 Hours of Device Implantation: A Pilot Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
- Computational prediction of the effect of D172N KCNJ2 mutation on ventricular pumping during sinus rhythm and reentry.Medical & biological engineering & computing · 2020Article
- 4D cardiac electromechanical activation imaging.Computers in biology and medicine · 2019Article
- Computational Prediction of the Combined Effect of CRT and LVAD on Cardiac Electromechanical Delay in LBBB and RBBB.Computational and mathematical methods in medicine · 2018Article
- Electromechanical wave imaging and electromechanical wave velocity estimation in a large animal model of myocardial infarction.Physics in medicine and biology · 2017Article
- Organ-level validation of a cross-bridge cycling descriptor in a left ventricular finite element model: effects of ventricular loading on myocardial strains.Physiological reports · 2017Article
- Reproducibility and Angle Independence of Electromechanical Wave Imaging for the Measurement of Electromechanical Activation during Sinus Rhythm in Healthy Humans.Ultrasound in medicine & biology · 2017Article
- Imaging the Propagation of the Electromechanical Wave in Heart Failure Patients with Cardiac Resynchronization Therapy.Pacing and clinical electrophysiology : PACE · 2017Review
- Electromechanical wave imaging (EWI) validation in all four cardiac chambers with 3D electroanatomic mapping in canines in vivo.Physics in medicine and biology · 2016Article
- Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations.Computers in biology and medicine · 2015Review
- A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles.Frontiers in bioengineering and biotechnology · 2015Article
- Images as drivers of progress in cardiac computational modelling.Progress in biophysics and molecular biology · 2014Review
- Electromechanical wave imaging of biologically and electrically paced canine hearts in vivo.Ultrasound in medicine & biology · 2014Article
- Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study.American journal of physiology. Heart and circulatory physiology · 2013Article
- A clinical feasibility study of atrial and ventricular electromechanical wave imaging.Heart rhythm · 2013Article
- A comprehensive multiscale framework for simulating optogenetics in the heart.Nature communications · 2013Article
- Effects of mechano-electric feedback on scroll wave stability in human ventricular fibrillation.PloS one · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElectromechanical wave imaging (EWI) is an entirely noninvasive, ultrasound-based imaging method capable of mapping the electromechanical activation sequence of the ventricles in vivo. Given the broad accessibility of ultrasound scanners in the clinic, the application of EWI could constitute a flexible surrogate for the 3-dimensional electrical activation.
objectiveThe purpose of this report is to reproduce the electromechanical wave (EW) using an anatomically realistic electromechanical model, and establish the capability of EWI to map the electrical activation sequence in vivo when pacing from different locations.
methodsEWI was performed in 1 canine during pacing from 3 different sites. A high-resolution dynamic model of coupled cardiac electromechanics of the canine heart was used to predict the experimentally recorded electromechanical wave. The simulated 3-dimensional electrical activation sequence was then compared with the experimental EW.
resultsThe electrical activation sequence and the EW were highly correlated for all pacing sites. The relationship between the electrical activation and the EW onset was found to be linear, with a slope of 1.01 to 1.17 for different pacing schemes and imaging angles.
conclusionThe accurate reproduction of the EW in simulations indicates that the model framework is capable of accurately representing the cardiac electromechanics and thus testing new hypotheses. The one-to-one correspondence between the electrical activation and the EW sequences indicates that EWI could be used to map the cardiac electrical activity. This opens the door for further exploration of the technique in assisting in the early detection, diagnosis, and treatment monitoring of rhythm dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.