ArticleNeuropharmacology2011
Restraint stress-induced reduction in prepulse inhibition in Brown Norway rats: role of the CRF2 receptor.
Article in Neuropharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Quetiapine ameliorates sensorimotor gating, recognition memory, and neuroendocrine plasticity in chronic stress-induced female rats.Metabolic brain disease · 2026Article
- Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala.Neuroscience · 2025Article
- Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala.bioRxiv : the preprint server for biology · 2025Article
- Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex.Neurobiology of stress · 2022Article
- Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?Journal of neuroendocrinology · 2022Review
- Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation.Frontiers in psychiatry · 2019Article
- Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice.Schizophrenia bulletin · 2014Article
- Effects of intracerebroventricular corticotropin releasing factor on sensory-evoked responses in the rat visual thalamus.Brain research · 2014Article
- Effects of stress, acute alcohol treatment, or both on pre-pulse inhibition in high- and low-alcohol preferring mice.Alcohol (Fayetteville, N.Y.) · 2014Article
- Partial genetic deletion of neuregulin 1 and adolescent stress interact to alter NMDA receptor binding in the medial prefrontal cortex.Frontiers in behavioral neuroscience · 2014Article
- The impact of hemodynamic stress on sensory signal processing in the rodent lateral geniculate nucleus.Brain research · 2013Article
- Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors.PloS one · 2013Article
- Enduring sensorimotor gating abnormalities following predator exposure or corticotropin-releasing factor in rats: a model for PTSD-like information-processing deficits?Neuropharmacology · 2012Article
- Interactions between corticotropin-releasing factor and the serotonin 1A receptor system on acoustic startle amplitude and prepulse inhibition of the startle response in two rat strains.Neuropharmacology · 2012Article
- Fos expression following regimens of predator stress versus footshock that differentially affect prepulse inhibition in rats.Physiology & behavior · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Stress plays a role in many psychiatric disorders that are characterized by deficits in prepulse inhibition (PPI), a form of sensorimotor gating. Corticotropin-releasing factor (CRF) is one of the most important neurotransmitters involved in behavioral components of the stress response. Central infusion of CRF reduces PPI in both rats and mice. In mice, it has been shown that CRF(1) receptor activation mediates the effect of exogenous CRF on PPI. However, the roles of the two CRF receptors in a stress-induced reduction in PPI are not known. We sought to determine whether CRF(1) and/or CRF(2) receptor blockade attenuates a stress-induced reduction of PPI in rats. In separate experiments, we assessed PPI in Brown Norway rats after exposure to 5 days of 2-h restraint, and after pretreatment with the CRF(1) receptor antagonist, CP-154,526 (20.0 mg/kg), or the CRF(2) receptor antagonist, antisauvagine-30 (10.0 μg). Repeated, but not acute, restraint decreased PPI and attenuated the increase in PPI caused by repeated PPI testing. Blockade of the CRF(1) receptor did not attenuate the effect of repeated restraint on PPI or grooming behavior. While CRF(2) receptor blockade did attenuate the effect of repeated restraint on PPI, repeated ICV infusion of the selective CRF(2) receptor agonist urocortin III, did not affect PPI. These findings demonstrate the effect of stress on sensorimotor gating and suggest that the CRF(2) receptor mediates this effect in rats.
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