ArticleNeuropharmacology2011
A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission.
Article in Neuropharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption.The FEBS journal · 2015Pooled it
- High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABANeurobiology of learning and memory · 2021Article
- Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders.Alcoholism, clinical and experimental research · 2021Article
- Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance.PloS one · 2020Article
- Systems genetics of sensation seeking.Genes, brain, and behavior · 2019Article
- Article
- Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse.BMC genomics · 2018Article
- Genome characterization of the selected long- and short-sleep mouse lines.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- From integrative genomics to systems genetics in the rat to link genotypes to phenotypes.Disease models & mechanisms · 2016Review
- Genes and Alcohol Consumption: Studies with Mutant Mice.International review of neurobiology · 2016Review
- Quantitative trait locus mapping of acute functional tolerance in the LXS recombinant inbred strains.Alcoholism, clinical and experimental research · 2015Article
- Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Genetics of gene expression characterizes response to selective breeding for alcohol preference.Genes, brain, and behavior · 2014Article
- Genetic influences on brain gene expression in rats selected for tameness and aggression.Genetics · 2014Article
- Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics.Biological psychiatry · 2014Article
- Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice.Genes, brain, and behavior · 2014Article
- The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations.Nucleic acids research · 2014Article
- Introduction to sequencing the brain transcriptome.International review of neurobiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic influences on the predisposition to complex behavioral or physiological traits can reflect genetic polymorphisms that lead to altered gene product function, and/or variations in gene expression levels. We have explored quantitative variations in an animal's alcohol consumption, using a genetical genomic/phenomic approach. In our studies, gene expression is correlated with amount of alcohol consumed, and genomic regions that regulate the alcohol consumption behavior and the quantitative levels of gene expression (behavioral and expression quantitative trait loci [QTL]) are determined and used as a filter to identify candidate genes predisposing the behavior. We determined QTLs for alcohol consumption using the LXS panel of recombinant inbred mice. We then identified genes that were: 1) differentially expressed between five high and five low alcohol-consuming lines or strains of mice; and 2) were physically located in, or had an expression QTL (eQTL) within the alcohol consumption QTLs. Comparison of mRNA and protein levels in brains of high and low alcohol consuming mice led us to a bioinformatic examination of potential regulation by microRNAs of an identified candidate transcript, Gnb1 (G protein beta subunit 1). We combined our current analysis with our earlier work identifying candidate genes for the alcohol consumption trait in mice, rats and humans. Our overall analysis leads us to postulate that the activity of the GABAergic system, and in particular GABA release and GABA receptor trafficking and signaling, which involves G protein function, contributes significantly to genetic variation in the predisposition to varying levels of alcohol consumption. This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.