ArticleThe Journal of allergy and clinical immunology2011
Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 75 citations in OpenAlex.
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- Genomic analysis, immunomodulation and deep phenotyping of patients with nodding syndrome.Brain : a journal of neurology · 2023Article
- Human IgE mAbs identify major antigens of parasitic worm infection.The Journal of allergy and clinical immunology · 2022Article
- Concordance of skin test reactivity between indoor inhalant allergens among children with allergic respiratory disease.BMC pediatrics · 2021Article
- Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins.PLoS pathogens · 2021Article
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- New highly antigenic linear B cell epitope peptides from PvAMA-1 as potential vaccine candidates.PloS one · 2021Article
- House Dust Mite Allergy Under Changing Environments.Allergy, asthma & immunology research · 2019Review
- Parasites and allergy: Observations from Africa.Parasite immunology · 2019Review
- Do helminth infections underpin urban-rural differences in risk factors for allergy-related outcomes?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.Science immunology · 2018Article
- Schistosoma mansoni-specific immune responses and allergy in Uganda.Parasite immunology · 2018Article
- A case of atopic dermatitis caused byClinical and molecular allergy : CMA · 2018Article
- Influence of Parasitic Worm Infections on Allergy Diagnosis in Sub-Saharan Africa.Current allergy and asthma reports · 2017Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe hygiene hypothesis suggests that parasitic infection modulates host immune responses and decreases atopy. Other data suggest parasitic infections may induce allergic responsiveness.
objectiveTo assess the structural and immunologic relationships between the known Dermatophagoides pteronyssinus (Der p 10) tropomyosin allergen and filarial tropomyosin of Onchocerca volvulus (OvTrop).
methodsThe molecular, structural, and immunologic relationships between OvTrop and Der p 10 were compared. Levels of OvTrop-specific and Der p 10-specific IgE, IgG, and IgG₄ in sera of filaria-infected and filarial-uninfected D pteronyssinus-atopic individuals were compared, as were the responses in nonhuman primates infected with the filarial parasite Loa loa. Cross-reactivity was compared by antigen-mediated depletion assays and functionality by passive basophil sensitization.
resultsFilarial and mite tropomyosins were very similar, with 72% identity at the amino acid level, and overlapping predicted 3-dimensional structures. The prevalence of IgE and IgG to Der p 10 was increased in filaria-infected individuals compared with uninfected subjects. There was a strong correlation between serum levels of Ov- and Der p 10-tropomyosin-specific IgE, IgG, and IgG₄ (P < .0001; r > 0.79). Preincubation of sera from anti-Der p 10-positive subjects with OvTrop completely depleted IgE, IgG, and IgG₄ anti-Der p 10. Basophils sensitized with sera from individuals allergic to Der p 10 released histamine similarly when triggered with OvTrop or Der p 10. Primates experimentally infected with L loa developed IgE that cross-reacted with Der p 10.
conclusionFilarial infection induces strong cross-reactive antitropomyosin antibody responses that may affect sensitization and regulation of allergic reactivity.
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