ArticleMolecular and cellular endocrinology2011
RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids.
Article in Molecular and cellular endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Function of manchette and intra-manchette transport in spermatogenesis and male fertility.Cell communication and signaling : CCS · 2025Review
- SPEM1 Gene Mutation in a Case with Sperm Morphological Defects Leading to Male Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints.Molecular ecology · 2024Article
- Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice.Cellular and molecular life sciences : CMLS · 2024Article
- Identification and analysis of differentially expressed (DE) circRNA in epididymis of yak and cattleyak.Frontiers in veterinary science · 2023Article
- The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.BMC cancer · 2022Article
- Sperm bauplan and function and underlying processes of sperm formation and selection.Physiological reviews · 2022Review
- Sperm Differentiation: The Role of Trafficking of Proteins.International journal of molecular sciences · 2020Review
- A Risk Classification System With Five-Gene for Survival Prediction of Glioblastoma Patients.Frontiers in neurology · 2019Article
- Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.JCI insight · 2018Article
- The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon's head to tail.Cell death & disease · 2016Review
- Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice.Cell death and differentiation · 2014Article
- The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis.Asian journal of andrology · 2013Article
- Proteomic analyses reveal a role of cytoplasmic droplets as an energy source during epididymal sperm maturation.PloS one · 2013Article
- Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways.Cellular and molecular life sciences : CMLS · 2012Review
- MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway.The Journal of biological chemistry · 2012Article
- The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans.Developmental biology · 2012Article
- The dynamic cytoskeleton of the developing male germ cell.Biology of the cell · 2012Review
- STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein.Histochemistry and cell biology · 2012Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
We identified Ran-binding protein 17 (RANBP17) as one of the interacting partners of sperm maturation 1 (SPEM1) using yeast 2-hybrid screening and immunoprecipitation assays. Expression profiling analyses suggested that RANBP17 was preferentially expressed in the testis. Immunofluorescent confocal microscopy revealed a dynamic localization pattern of RANBP17 during spermatogenesis. In primary spermatocytes RANBP17 was mainly localized to the XY body. In the subsequent spermiogenesis, RANBP17 was first observed in the nuclei of round spermatids (steps 1-7) and then confined to the manchette of elongating spermatids (steps 8-14) together with its interacting partner SPEM1. In the Spem1-null testes, levels of RANBP17 were significantly elevated. As a member of a large protein family involved in the nucleocytoplasmic transport, RANBP17 may have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and also in the intramanchette transport during spermiogenesis. Interactions between RANBP17 and SPEM1, for the first time, point to a potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport.
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