Trial reportCritical care (London, England)2010
Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit.
Trial report in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01250080 (Effect of Gutamine Administration in the Innate Immune System Response in ICU Patients.), which is not on this map. Cited by 18 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Gutamine Administration in the Innate Immune System Response in ICU Patients.
Who cites it
18 citing papers in PubMed, 7 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Heterogeneity of surrogate outcome measures used in critical care studies: A systematic review.Clinical trials (London, England) · 2023Pooled it
- Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2015Pooled it
- Glutamine Supplementation in Intensive Care Patients: A Meta-Analysis of Randomized Clinical Trials.Medicine · 2015Pooled it
- Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumor: a meta-analysis of randomized controlled trials.Chinese medical journal · 2015Pooled it
- Glutamine supplementation for critically ill adults.The Cochrane database of systematic reviews · 2014Pooled it
- Parenteral glutamine supplementation in critical illness: a systematic review.Critical care (London, England) · 2014Pooled it
- The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2014Pooled it
- Dental-derived stem cells in tissue engineering: the role of biomaterials and host response.Regenerative biomaterials · 2024Review
- Alterations of Phagocytic Activity and Capacity in Granulocytes and Monocytes Depend on the Pathogen Strain in Porcine Polytrauma.Frontiers in medicine · 2021Article
- Glutamine supplementation in trauma ICU patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Association between Modified Body Mass Index and 30-Day and 1-Year Mortality after Intensive Care Unit Admission: A Retrospective Cohort Study.Journal of clinical medicine · 2018Article
- Glutamine in critically ill patients: is it a fundamental nutritional supplement?Revista Brasileira de terapia intensiva · 2016Article
- Exogenous Glutamine in Respiratory Diseases: Myth or Reality?Nutrients · 2016Review
- Current views on the mechanisms of immune responses to trauma and infection.Central-European journal of immunology · 2015Review
- Glutamine may repress the weak LPS and enhance the strong heat shock induction of monocyte and lymphocyte HSP72 proteins but may not modulate the HSP72 mRNA in patients with sepsis or trauma.BioMed research international · 2015Article
- Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition.Central-European journal of immunology · 2015Article
- The systemic immune response to trauma: an overview of pathophysiology and treatment.Lancet (London, England) · 2014Review
- Mitochondria: sensors and mediators of innate immune receptor signaling.Current opinion in microbiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe use of glutamine as a dietary supplement is associated with a reduced risk of infection. We hypothesized that the underlying mechanism could be an increase in the expression and/or functionality of Toll-like receptors (TLR), key receptors sensing infections. The objective of this study was to evaluate whether glutamine supplementation alters the expression and functionality of TLR2 and TLR4 in circulating monocytes of trauma patients admitted to the intensive care unit (ICU).
methodsWe designed a prospective, randomized and single-blind study. Twenty-three patients received parenteral nutrition (TPN) with a daily glutamine supplement of 0.35 g/kg. The control group (20 patients) received an isocaloric-isonitrogenated TPN. Blood samples were extracted before treatment, at 6 and 14 days. Expression of TLR2 and TLR4 was determined by flow cytometry. Monocytes were stimulated with TLR specific agonists and cytokines were measured in cell culture supernatants. Phagocytic ability of monocytes was also determined.
resultsBasal characteristics were similar in both groups. Monocytes from patients treated with glutamine expressed the same TLR2 levels as controls before treatment (4.9 ± 3.5 rmfi vs. 4.3 ± 1.9 rmfi, respectively; P = 0.9), at Day 6 (3.8 ± 2.3 rmfi vs. 4.0 ± 1.7 rmfi, respectively; P = 0.7) and at Day 14 (4.1 ± 2.1 rfim vs. 4.6 ± 1.9 rmfi, respectively; P = 0.08). TLR4 levels were not significantly different between the groups before treatment: (1.1 ± 1 rmfi vs 0.9 ± 0.1 rmfi respectively; P = 0.9), at Day 6 (1.1 ± 1 rmfi vs. 0.7 ± 0.4 rmfi respectively; P = 0.1) and at Day 14 (1.4 ± 1.9 rmfi vs. 1.0 ± 0.6 rmfi respectively; P = 0.8). No differences in cell responses to TLR agonists were found between groups. TLR functionality studied by phagocytosis did not vary between groups.
conclusionsIn trauma patients in the intensive care unit, TPN supplemented with glutamine does not improve the expression or the functionality of TLRs in peripheral blood monocytes.
trial registrationClinicalTrials.gov Identifier: NCT01250080.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.