ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
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- Genome-wide association study of delay discounting in Heterogeneous Stock rats.Genes, brain, and behavior · 2024Article
- Genome-wide association study of delay discounting in Heterogenous Stock rats.bioRxiv : the preprint server for biology · 2023Article
- ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.Scientific reports · 2022Article
- An assessment of executive function in two different rat models of attention-deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats.Genes, brain, and behavior · 2021Article
- Article
- Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers.Neurobiology of disease · 2019Article
- Article
- ADGRL3 (LPHN3) variants predict substance use disorder.Translational psychiatry · 2019Article
- Article
- Antivenom Efficacy in Neutralizing Histopathological Complications FollowingJournal of arthropod-borne diseases · 2017Article
- Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans.Journal of human genetics · 2017Article
- Article
- ADGRL3 (LPHN3) variants are associated with a refined phenotype of ADHD in the MTA study.Molecular genetics & genomic medicine · 2016Article
- Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction.Molecular genetics & genomic medicine · 2016Article
- Review
- Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior.Frontiers in neuroscience · 2015Review
- Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD).European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2013Article
- The genetics of attention deficit/hyperactivity disorder in adults, a review.Molecular psychiatry · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The findings of a recent study associate LPHN3, a member of the latrophilin family, with an increased risk of developing attention deficit/hyperactivity disorder (ADHD), the most common psychiatric disorder in childhood and adolescence. Latrophilins comprise a new family of G protein-coupled receptors of unknown native physiological function that mediate the neurotoxic effects of α-latrotoxin, a potent toxin found in black widow spider venom. This receptor-toxin interaction has helped to elucidate the mechanistic aspects of neurotransmitter and hormone release in vertebrates. Such unprecedented discovery points to a new direction in the assessment of ADHD and suggest that further study of this receptor family may provide novel insights into the etiology and treatment of ADHD and other related psychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.