Evidence map›Paper›PMID 21184165›Full record

ArticleBehavior genetics2011

Genetical genomic analysis of complex phenotypes using the PhenoGen website.

Beth Bennett, Laura M Saba, Cheryl K Hornbaker, Katerina J Kechris, Paula Hoffman, Boris Tabakoff

Abstract read
In one paragraph

Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beth BennettDepartment of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045-0511, USA. beth.bennett@ucdenver.edu
Laura M Saba
Cheryl K Hornbaker
Katerina J Kechris
Paula Hoffman
Boris Tabakoff

Funding

The Heritable Transcriptome and AlcoholismR24AA013162 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HOFFMAN, PAULA, SABA, LAURA MAREN · 2001 to 2021
$14.2M
Regulation of alcohol consumption by chromatin modificationU01AA016649 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HOFFMAN, PAULA, TABAKOFF, BORIS · 2006 to 2013
$2.4M
Colorado Gene Array CoreU01AA016663 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI TABAKOFF, BORIS · 2006 to 2010
$2.2M
Genomic regulatory sequence analysis for alcohol-related phenotypesK01AA016922 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI KECHRIS-MAYS, KATHERINA · 2007 to 2011
$737k
Alcohol-induced dysregulation of thiol homeostasis and endothelial functionR21AA026922 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAN, JINGYAN, ZANG, MENGWEI · 2019 to 2020
$439k
NIAAA NIH HHS K01AA026922NIAAA NIH HHS R21 AA026922NIAAA NIH HHS R24 AA013162NIAAA NIH HHS R24AA013162NIAAA NIH HHS U01 AA016649NIAAA NIH HHS U01AA016649NIAAA NIH HHS U01 AA016663NIAAA NIH HHS U01AA016663
6 · The paper itself

Abstract

Our laboratory has developed an online interactive resource called PhenoGen ( http://phenogen.ucdenver.edu ) which provides an archive of brain and other organ gene expression data from a panel of 20 common inbred mouse strains, and three recombinant inbred (RI) panels (two mouse and one rat). DNA microarray data can also be uploaded to the site where numerous analytical tools can be implemented. An important advantage to the archived data is that each array represents data from a single animal and each strain was sampled 4-7 times, providing an estimate of genetic variance (heritability) of individual transcript levels. These panels also allow genetic mapping of expression QTLs. Overlap of eQTLs with phenotypic QTLs provides a powerful approach to candidate gene identification. These methods are briefly described here and we encourage the use of our site for both scientific discovery and as a teaching tool in quantitative genetics.

Indexed as

GenomeAnimalsChromosome MappingCrosses, GeneticGene Expression ProfilingGenetics, BehavioralInternetMiceModels, GeneticOligonucleotide Array Sequence AnalysisPhenotypePolymorphism, Single NucleotideQuantitative Trait LociRNA, MessengerSoftwareRNA, Messenger

Identifiers

PMID21184165
PMCPMC3121939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.