ArticleBehavior genetics2011
Sex-specific heterosis in line crosses of mice selectively bred for high locomotor activity.
Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Enhanced metabolic benefits of dietary methionine restriction in cold resistant hybrid UCP1-deficient mice.The Journal of nutritional biochemistry · 2026Article
- Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice?Behavior genetics · 2025Article
- Maternal upbringing and selective breeding for voluntary exercise behavior modify patterns of DNA methylation and expression of genes in the mouse brain.Genes, brain, and behavior · 2023Article
- Article
- Rapid and longer-term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice.Journal of anatomy · 2021Article
- Long-Term Regular Eccentric Exercise Decreases Neuropathic Pain-like Behavior and Improves Motor Functional Recovery in an Axonotmesis Mouse Model: the Role of Insulin-like Growth Factor-1.Molecular neurobiology · 2018Article
- Sex-dependent differences in voluntary physical activity.Journal of neuroscience research · 2017Review
- The signature of fine scale local adaptation in Atlantic salmon revealed from common garden experiments in nature.Evolutionary applications · 2015Article
- High-saturated fat-sucrose feeding affects lactation energetics in control mice and mice selectively bred for high wheel-running behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Aging in the cerebellum and hippocampus and associated behaviors over the adult life span of CB6F1 mice.Neuroscience · 2013Article
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Authors and funding
6 authors.
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Abstract
When populations with similar histories of directional selection are crossed, their offspring may differ in mean phenotype as compared with the average for the parental populations, often exhibiting enhancement of the mean phenotype (termed heterosis or hybrid vigor). We tested for heterosis in a cross of two replicate lines of mice selectively bred for high voluntary wheel running for 53 generations. Mice were paired to produce four sets of F1 offspring: two purebred High Runner (HR) lines and the hybrid reciprocal crosses. The purebred HR showed statistically significant, sex-dependent differences in body mass, wheel revolutions, running duration, mean running speed, and (controlling for body mass) organ masses (heart ventricles, liver, spleen, triceps surae muscle). Hybrid males ran significantly more revolutions than the purebred males, mainly via increased running speeds, but hybrid females ran intermediate distances, durations, and speeds, as compared with the purebred females. In both sexes, ventricles were relatively smaller in hybrids as compared with purebred HR. Overall, our results demonstrate differential and sex-specific responses to selection in the two HR lines tested, implying divergent genetic architectures underlying high voluntary exercise.
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