ArticleLasers in medical science2011
Low-level laser therapy (LLLT) acts as cAMP-elevating agent in acute respiratory distress syndrome.
Article in Lasers in medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The Probable Protective Effect of Photobiomodulation on the Inflammation of the Airway and Lung in COVID-19 Treatment: A Preclinical and Clinical Meta-Analysis.Advances in experimental medicine and biology · 2022Pooled it
- Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review.Cytokine · 2021Pooled it
- Cardiopulmonary and hematological effects of infrared LED photobiomodulation in the treatment of SARS-COV2.Journal of photochemistry and photobiology. B, Biology · 2023Trial
- Photobiomodulation Improves Serum Cytokine Response in Mild to Moderate COVID-19: The First Randomized, Double-Blind, Placebo Controlled, Pilot Study.Frontiers in immunology · 2022Trial
- Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial.Journal of inflammation research · 2021Trial
- Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial.Lasers in medical science · 2014Trial
- Effects of Photobiomodulation on Ventilatory Mechanics and Inflammatory Response in a Rat Model of Acute Lung Injury.Journal of lasers in medical sciences · 2026Article
- The Clinical Effects of Laser Acupuncture on Hospitalized Patients With Severe COVID-19: A Randomized Clinical Trial.Journal of lasers in medical sciences · 2023Article
- Influence of photobiomodulation therapy on the treatment of pulmonary inflammatory conditions and its impact on COVID-19.Lasers in medical science · 2022Article
- The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review.Stem cell reviews and reports · 2021Review
- Photobiomodulation therapy as a high potential treatment modality for COVID-19.Lasers in medical science · 2021Review
- Early cases of acute infectious respiratory syndrome treated with photobiomodulation, diagnosis and intervention: Two case reports.Clinical case reports · 2021Article
- Photobiomodulation and Antiviral Photodynamic Therapy in COVID-19 Management.Advances in experimental medicine and biology · 2021Article
- Wavelength- and irradiance-dependent changes in intracellular nitric oxide level.Journal of biomedical optics · 2020Article
- Low level laser therapy as a modality to attenuate cytokine storm at multiple levels, enhance recovery, and reduce the use of ventilators in COVID-19.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2020Article
- Aging of lymphoid organs: Can photobiomodulation reverse age-associated thymic involution via stimulation of extrapineal melatonin synthesis and bone marrow stem cells?Journal of biophotonics · 2018Review
- Anti-inflammatory effects of low-level laser therapy on human periodontal ligament cells: in vitro study.Lasers in medical science · 2018Article
- Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure.PloS one · 2015Article
- Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Low-level laser therapy improves the inflammatory profile of rats with heart failure.Lasers in medical science · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to investigate if the low-level laser therapy (LLLT) on acute lung inflammation (ALI) induced by lipopolysaccharide (LPS) is linked to tumor necrosis factor (TNF) in alveolar macrophages (AM) from bronchoalveolar lavage fluid (BALF) of mice. LLLT has been reported to actuate positively for relieving the late and early symptoms of airway and lung inflammation. It is not known if the increased TNF mRNA expression and dysfunction of cAMP generation observed in ALI can be influenced by LLLT. For in vivo studies, Balb/c mice (n = 5 for group) received LPS inhalation or TNF intra nasal instillation and 3 h after LPS or TNF-α, leukocytes in BALF were analyzed. LLLT administered perpendicularly to a point in the middle of the dissected bronchi with a wavelength of 660 nm and a dose of 4.5 J/cm(2). The mice were irradiated 15 min after ALI induction. In vitro AM from mice were cultured for analyses of TNF mRNA expression and protein and adenosine3':5'-cyclic monophosphate (cAMP) levels. One hour after LPS, the TNF and cAMP levels in AM were measured by ELISA. RT-PCR was used to measure TNF mRNA in AM. The LLLT was inefficient in potentiating the rolipram effect in presence of a TNF synthesis inhibitor. LLLT attenuated the neutrophil influx and TNF in BALF. In AM, the laser increased the cAMP and reduced the TNF-α mRNA. LLLT increases indirectly the cAMP in AM by a TNF-dependent mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.