ReviewDer Anaesthesist2011
[Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage].
Review in Der Anaesthesist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- A case of a lidocaine intoxication of a 12 week old boy due to a circumcision in a domestic setting - clinical, toxicological and forensic aspects.Forensic science, medicine, and pathology · 2025Article
- Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies.Journal of molecular medicine (Berlin, Germany) · 2024Review
- Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence.Frontiers in oncology · 2021Review
- [Perioperative measures for prevention of phantom pain: an evidence-based approach to risk reduction].Der Anaesthesist · 2020Review
- [Stocktaking of local anesthetics 2020].Der Anaesthesist · 2020Review
- Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review.F1000Research · 2020Review
- Efficacy of intravenous lidocaine in improving post-operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery.Experimental and therapeutic medicine · 2019Article
- Chronified Pain Following Operative Procedures.Deutsches Arzteblatt international · 2019Article
- [Pain therapy in intensive care patients].Der Anaesthesist · 2018Review
- Analgesic therapy for major spine surgery.Neurosurgical review · 2015Review
- [Perioperative pain management for abdominal and thoracic surgery].Schmerz (Berlin, Germany) · 2014Review
- [Update on the pharmacology and effects of local anesthetics].Der Anaesthesist · 2014Review
- [Interaction of anesthetics and analgesics with tumor cells].Der Anaesthesist · 2014Review
- [ECG changes in patients with chronic non-cancer pain: a prospective observational study].Schmerz (Berlin, Germany) · 2012Article
- [Anesthesia for geriatric patients : Part 2: anesthetics, patient age and anesthesia management].Der Anaesthesist · 2012Review
- [Anesthesia for geriatric patients. Part 1: age, organ function and typical diseases].Der Anaesthesist · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lidocaine is commonly used for regional anesthesia and nerve blocks. However, recent clinical studies demonstrated that intravenous perioperative administration of lidocaine can lead to better postoperative analgesia, reduced opioid consumption and improved intestinal motility. It can therefore be used as an alternative when epidural analgesia is contraindicated, not possible or not feasible. Apart from the sodium channel blocking effects relevant for regional anesthesia, lidocaine also has anti-inflammatory properties. Lidocaine can obviously inhibit the priming of resting neutrophilic granulocytes, which, simplified, may reduce the liberation of superoxide anions, a common pathway of inflammation after multiple forms of tissue trauma. At the authors' institutions intravenous lidocaine is primarily used for postoperative pain relief following abdominal surgery and is given as a bolus dose of 1.5-2.0 mg/kg body weight (BW) injected over 5 min followed by an infusion of 1.5 mg/kg BW/h intraoperatively and 1.33 mg/kg BW/h postoperatively in the recovery room or in the intensive care unit (ICU). The lidocaine infusion is stopped in the recovery room 30 min before discharge or in the ICU at the latest after 24 h. Lidocaine is not used on normal wards. This overview summarizes the current evidence for the intravenous administration of lidocaine for patients undergoing different types of surgery and gives practical advice for its use.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.