Evidence map›Paper›PMID 21183785›Full record

ArticleThe Journal of clinical investigation2011

Cytokinesis failure and attenuation: new findings in Fanconi anemia.

Philip J Mason, Monica Bessler

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Philip J MasonDivision of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA. masonp@email.chop.edu
Monica Bessler
Children's Hospital of Philadelphia · US

Funding

MOLECULAR STUDIES OF BONE MARROW FAILURER01CA105312 · NCI · WASHINGTON UNIVERSITY · PI BESSLER, MONICA · 2004 to 2014
$4.9M
THE PATHOGENESIS OF DYSKERATOSIS CONGENITAR01CA106995 · NCI · WASHINGTON UNIVERSITY · PI MASON, PHILIP J · 2005 to 2014
$3.0M
NCI NIH HHS R01 CA105312NCI NIH HHS R01 CA106995
6 · The paper itself

Abstract

The hallmarks of the rare inherited disorder Fanconi anemia (FA) are progressive bone marrow failure and susceptibility to cancer. The former is the major cause of death for patients with FA, as it usually occurs earlier in life than cancer development. Despite spectacular advances in unraveling the molecular details of FA, the origin of the bone marrow failure that is central to this condition for most patients has long been puzzling and controversial. Two studies recently published in the JCI, including one in this issue, will add to the debate. They also highlight the fact that studying rare disorders can elucidate important new clinical and biological principles.

Indexed as

CytokinesisBone Marrow CellsFanconi AnemiaG2 PhaseHumansLeukemiaModels, Biological

Identifiers

PMID21183785
PMCPMC3007166
OpenAlexW2169915145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.