ArticleAJNR. American journal of neuroradiology2011
Functional MR imaging evidence of altered functional activation in metabolic syndrome.
Article in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.The American journal of clinical nutrition · 2013Trial
- MRI-based insights into brain structural and functional alterations in schizophrenia treated with risperidone.Frontiers in psychiatry · 2025Review
- Metabolic syndrome components moderate the association between executive function and functional connectivity in the default mode network.Brain imaging and behavior · 2021Article
- Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury-a Review.Obesity surgery · 2020Review
- Aberrant patterns of default-mode network functional connectivity associated with metabolic syndrome: A resting-state study.Brain and behavior · 2019Article
- Structural and Functional Brain Connectivity Changes Between People With Abdominal and Non-abdominal Obesity and Their Association With Behaviors of Eating Disorders.Frontiers in neuroscience · 2018Article
- Posttraumatic stress disorder: A metabolic disorder in disguise?Experimental neurology · 2016Review
- The Effects of Aerobic Exercise on Cognitive and Neural Decline in Aging and Cardiovascular Disease.Current geriatrics reports · 2014Article
- Subclinical vascular disease and cerebral glutamate elevation in metabolic syndrome.Metabolic brain disease · 2012Article
- Impact of metabolic syndrome on cognition and brain: a selected review of the literature.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
- Cognitive assessment in an elderly population with metabolic syndrome in Brazil.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMetS is a cluster of risk factors associated with significant cardiovascular morbidity and mortality and diminished cognitive function. Given that little is known about the early signs of brain vulnerability related to persistent metabolic dysfunction, we set out to determine whether cognitively healthy middle-aged individuals with MetS exhibit an altered cerebrovascular response to a cognitive challenge relative to those without MetS. MATERIALS AND
methodsForty neurologically healthy adults aged 40-60 years (19 with MetS and 21 healthy controls) performed a 2-back verbal working memory task during fMRI. We compared BOLD responses between the 2 groups in 8 a priori regions of interest previously shown to be associated with the 2-back in patients with cardiovascular disease.
resultsAge, education level, sex distribution, cognitive and emotional functioning, and task performance (accuracy and reaction time) were not different between the groups. Compared with healthy controls, individuals with MetS demonstrated a lower 2-back-related BOLD response in the right superior frontal gyrus, right superior parietal lobule, and left inferior parietal lobule.
conclusionsThis study provides preliminary evidence that cognitively intact middle-aged individuals with MetS exhibit significant alterations in cerebrovascular response to a cognitive challenge. Our results also demonstrate that fMRI may identify early brain changes associated with MetS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.