ArticleAJNR. American journal of neuroradiology2011
Aberrant diffusion and geometric properties in the left arcuate fasciculus of developmentally delayed children: a diffusion tensor imaging study.
Article in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- A Cross-Sectional Study of the Association between Infant Hepatitis B Vaccine Exposure in Boys and the Risk of Adverse Effects as Measured by Receipt of Special Education Services.International journal of environmental research and public health · 2018Article
- Relationship between genotype and arcuate fasciculus morphology in six young children with global developmental delay: Preliminary DTI stuy.Journal of magnetic resonance imaging : JMRI · 2016Article
- A longitudinal cohort study of the relationship between Thimerosal-containing hepatitis B vaccination and specific delays in development in the United States: Assessment of attributable risk and lifetime care costs.Journal of epidemiology and global health · 2016Article
- Differentiation of Speech Delay and Global Developmental Delay in Children Using DTI Tractography-Based Connectome.AJNR. American journal of neuroradiology · 2016Article
- The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development.AJNR. American journal of neuroradiology · 2016Article
- Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria.Behavioural neurology · 2015Article
- Thimerosal-containing hepatitis B vaccination and the risk for diagnosed specific delays in development in the United States: a case-control study in the vaccine safety datalink.North American journal of medical sciences · 2014Article
- Exome sequencing and diffusion tensor imaging in developmental disabilities.Pediatric research · 2014Article
- Independent contribution of individual white matter pathways to language function in pediatric epilepsy patients.NeuroImage. Clinical · 2014Article
- Curvature range measurements of the arcuate fasciculus using diffusion tensor tractography.Neural regeneration research · 2013Article
- Altered white matter structure of the dentatorubrothalamic pathway in children with autistic spectrum disorders.Cerebellum (London, England) · 2012Article
- Article
- Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay.The Journal of pediatrics · 2012Article
- A sensitive diffusion tensor imaging quantification method to detect language laterality in children: correlation with the Wada test.Journal of child neurology · 2011Article
- Probing the brain in autism using FMRI and diffusion tensor imaging.Journal of visualized experiments : JoVE · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeOne of the neurologic substrates of poor language in children with DD is the abnormal development of perisylvian language networks. We sought to determine whether this manifests as aberrant regional changes in diffusivity or geometry of the left AF. MATERIALS AND
methodsWe performed DTI studies in 16 young (age, 55.4 ± 18.95 months) patients with DD and 11 age- and sex-matched TD children (age, 60.09 ± 21.27 months). All children were right-handed. To detect the malformation of left AF structure in native or standard space, we proposed new methodology consisting of 2 complementary approaches, principal fiber orientation quantification in color-coded anisotropic maps and tract-based morphometry analysis.
resultsPatients with DD did not show the typical pattern of age-related maturity of the AP and ML pathways passing through the left AF (R(2) of the AP pathway: DD versus TD = 0.002 versus 0.4542; R(2) of the ML pathway: DD versus TD = 0.002 versus 0.4154). In addition, the patients with DD showed significantly reduced FA in the temporal portion of the AF (mean FA of DD versus TD = 0.37 ± 0.11 versus 0.48 ± 0.06, P < .001), and the AF showed higher curvatures in the parietotemporal junction, resulting in sharper bends to the Wernicke area (mean curvature of DD versus TD = 0.12 ± 0.03 versus 0.06 ± 0.02, P < .001).
conclusionsThe proposed methods successfully revealed regional abnormalities in the axonal integrity of the left AF in the patients with DD. These abnormalities support the notion that the perisylvian language network is malformed in children with DD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.