ArticleDisease models & mechanisms2011
Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems.
Article in Disease models & mechanisms, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
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- Valve cells are crucial for efficient cardiac performance in Drosophila.PLoS genetics · 2025Article
- Conserved chamber-specific polyploidy maintains heart function in Drosophila.Development (Cambridge, England) · 2023Article
- In-ovo echocardiography for application in cardiovascular research.Basic research in cardiology · 2023Article
- A mechanosensitive vascular niche forProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Regular Exercise inInternational journal of molecular sciences · 2023Article
- Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function.Journal of visualized experiments : JoVE · 2022Article
- Pupal size as a proxy for fat content in laboratory-reared and field-collected Drosophila species.Scientific reports · 2022Article
- Microfluidics for understanding model organisms.Nature communications · 2022Review
- Phenotyping ofBiomolecules · 2022Review
- Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.Frontiers in molecular neuroscience · 2022Review
- Three-dimensional analysis of the heart function and effect cholinergic agonists in the cockroach Gromphadorhina portentosa.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
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- Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology inBiology open · 2019Article
- The Effects of Chloride Flux onMethods and protocols · 2019Article
- Sources of CaJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Microfluidics for mechanobiology of model organisms.Methods in cell biology · 2018Article
- Using optogenetics to assess neuroendocrine modulation of heart rate in Drosophila melanogaster larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy (OCM).Journal of visualized experiments : JoVE · 2016Article
- Drosophila tools and assays for the study of human diseases.Disease models & mechanisms · 2016Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The physiology of the Drosophila melanogaster cardiovascular system remains poorly characterized compared with its vertebrate counterparts. Basic measures of physiological performance remain unknown. It also is unclear whether subtle physiological defects observed in the human cardiovascular system can be reproduced in D. melanogaster. Here we characterize the cardiovascular physiology of D. melanogaster in its pre-pupal stage by using high-speed dye angiography and optical coherence tomography. The heart has vigorous pulsatile contractions that drive intracardiac, aortic and extracellular-extravascular hemolymph flow. Several physiological measures, including weight-adjusted cardiac output, body-length-adjusted aortic velocities and intracardiac shear forces, are similar to those in the closed vertebrate cardiovascular systems, including that of humans. Extracellular-extravascular flow in the pre-pupal D. melanogaster circulation drives convection-limited fluid transport. To demonstrate homology in heart dysfunction, we showed that, at the pre-pupal stage, a troponin I mutant, held-up2 (hdp2), has impaired systolic and diastolic heart wall velocities. Impaired heart wall velocities occur in the context of a non-dilated phenotype with a mildly depressed fractional shortening. We additionally derive receiver operating characteristic curves showing that heart wall velocity is a potentially powerful discriminator of systolic heart dysfunction. Our results demonstrate physiological homology and support the use of D. melanogaster as an animal model of complex cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.