Evidence map›Paper›PMID 21182907›Full record

ArticleToxicology letters2011

Circadian clock disruption in the mouse ovary in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Shelley A Tischkau, Cassie D Jaeger, Stacey L Krager

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  7. Pharmacological Actions of Carbamate Insecticides at Mammalian Melatonin Receptors.The Journal of pharmacology and experimental therapeutics · 2021
    Article
  8. Review
  9. The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shelley A TischkauDepartment of Pharmacology, Southern Illinois University, School of Medicine, 801N. Rutledge, Springfield, IL 62794-9629, USA. stischkau@siumed.edu
Cassie D Jaeger
Stacey L Krager
Southern Illinois University School of Medicine · US

Funding

Circadian Clock Disruption: A Mechanism for Dioxin-induced Metabolic SyndromeR01ES017774 · NIEHS · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI TISCHKAU, SHELLEY A · 2010 to 2013
$1.3M
Environmental Toxins Disrupt Ovarian Circadian RhythmsR21ES012948 · NIEHS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI TISCHKAU, SHELLEY A · 2004 to 2005
$403k
NIEHS NIH HHS ES012948NIEHS NIH HHS ES017774NIEHS NIH HHS R01 ES017774NIEHS NIH HHS R21 ES012948
6 · The paper itself

Abstract

Activation of the aryl hydrocarbon receptor (AhR) by the highly toxic, prototypical ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or other dioxin-like compounds compromises ovarian function by altering follicle maturation and steroid synthesis. Although alteration of transcription after nuclear translocation and heterodimerization of AhR with its binding partner, aryl hydrocarbon nuclear transporter (ARNT), is often cited as a primary mechanism for mediating the toxic effects of dioxins, recent evidence indicates that crosstalk between AhR and several other signaling pathways also occurs. Like the circadian clock genes, AhR is a member of the basic helix-loop-helix, Per-ARNT-SIM (bHLH-PAS) domain family of proteins. Thus, these studies tested the hypothesis that TCDD can act to alter circadian clock regulation in the ovary. Adult female c57bl6/J mice entrained to a typical 12h light/12h dark cycle were exposed to a single 1 μg/kg dose of TCDD by gavage. Six days after exposure, animals were released into constant darkness and ovaries were collected every 4h over a 24h period. Quantitative real-time PCR and immunoblot analysis demonstrated that TCDD exposure alters expression of the canonical clock genes, Bmal1 and Per2 in the ovary. AhR transcript and protein, which displayed a circadian pattern of expression in the ovaries of control mice, were also altered after TCDD treatment. Immunohistochemistry studies revealed co-localization of AhR with BMAL1 in various ovarian cell types. Furthermore, co-immunoprecipitation demonstrated time-of-day dependent interactions of AhR with BMAL1 that were enhanced after TCDD treatment. Collectively these studies suggest that crosstalk between classical AhR signaling and the molecular circadian clockworks may be responsible for altered ovarian function after TCDD exposure.

Indexed as

AnimalsARNTL Transcription FactorsCircadian ClocksFemaleMiceMice, Inbred C57BLOvaryPeriod Circadian ProteinsPolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonARNTL Transcription FactorsBmal1 protein, mousePer2 protein, mousePeriod Circadian ProteinsPolychlorinated DibenzodioxinsReceptors, Aryl Hydrocarbon

Identifiers

PMID21182907
PMCPMC3039055
OpenAlexW2090097405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.