ReviewCurrent medicinal chemistry2011
Emerging role of antioxidants in the protection of uveitis complications.
Review in Current medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Pooled it
- Glucagon-Like Peptide-1 Receptor Agonists and Risk of Uveitis.JAMA ophthalmology · 2025Article
- Review
- Lutein Encapsulated in PLGA-Phospholipid Nano-Carrier Effectively Mitigates Cytokines by Inhibiting Tumor Necrosis Factor TNF-α and Nuclear Factor NF-Journal of functional biomaterials · 2023Article
- m6A Modification-Association with Oxidative Stress and Implications on Eye Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Protective effects of melatonin receptor agonists on endotoxin-induced uveitis in rats.Iranian journal of basic medical sciences · 2023Article
- Genetic Ablation of Nrf2 Exacerbates Neuroinflammation in Ocular Autoimmunity.International journal of molecular sciences · 2022Article
- Compositions and Biological Activities of Pomegranate Peel Polyphenols Extracted by Different Solvents.Molecules (Basel, Switzerland) · 2022Article
- Article
- Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum.International journal of molecular sciences · 2021Article
- Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights.Marine drugs · 2020Review
- Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma.Journal of ophthalmology · 2020Article
- Isolation and Identification of Lactic Acid Bacteria Probiotic Culture Candidates for the Treatment ofAnimals : an open access journal from MDPI · 2019Article
- Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs.American journal of ophthalmology · 2018Article
- Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation.Frontiers in pharmacology · 2018Article
- RES-loaded pegylated CS NPs: for efficient ocular delivery.IET nanobiotechnology · 2017Article
- Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation.Oxidative medicine and cellular longevity · 2015Article
- Oxidative stress to the cornea, changes in corneal optical properties, and advances in treatment of corneal oxidative injuries.Oxidative medicine and cellular longevity · 2015Review
- Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation.British journal of pharmacology · 2014Article
- Oxidative stress and its downstream signaling in aging eyes.Clinical interventions in aging · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Current understanding of the role of oxidative stress in ocular inflammatory diseases indicates that antioxidant therapy may be important to optimize the treatment. Recently investigated antioxidant therapies for ocular inflammatory diseases include various vitamins, plant products and reactive oxygen species scavengers. Oxidative stress plays a causative role in both non-infectious and infectious uveitis complications, and novel strategies to diminish tissue damage and dysfunction with antioxidant therapy may ameliorate visual complications. Preclinical studies with experimental animals and cultured cells demonstrate significant anti-inflammatory effects of a number of promising antioxidant agents. Many of these antioxidants are under clinical trial for various inflammatory diseases other than uveitis such as cardiovascular, rheumatoid arthritis and cancer. Well planned interventional clinical studies in the field of ocular inflammation will be necessary to sufficiently investigate the potential medical benefits of antioxidant therapies for uveitis. This review summarizes the recent investigations of novel antioxidant agents for ocular inflammation, with selected studies focused on uveitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.