ReviewWorld journal of gastroenterology2010
Hepatoprotective actions of melatonin: possible mediation by melatonin receptors.
Review in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Research Hot Spots and Trends on Melatonin From 2000 to 2019.Frontiers in endocrinology · 2021Pooled it
- Therapeutic and chemopreventive potential of melatonin in liver diseases: targeting oxidative stress and inflammatory signaling.Frontiers in pharmacology · 2026Review
- Melatonin protect against pregabalin-induced gonadotoxicity via anti-oxidative, anti-inflammatory, anti-apoptotic, enzymatic and hormonal regulatory mechanisms in rats.BMC pharmacology & toxicology · 2025Article
- Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Protective Effects of Melatonin in High-Fat Diet-Induced Hepatic Steatosis via Decreased Intestinal Lipid Absorption and Hepatic Cholesterol Synthesis.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Protective effect of melatonin against herbicides-induced hepatotoxicity in rats.Toxicology research · 2021Article
- Melatonin for the treatment of sepsis: the scientific rationale.Journal of thoracic disease · 2020Review
- Topical Melatonin Improves Gastric Microcirculatory Oxygenation During Hemorrhagic Shock in Dogs but Does Not Alter Barrier Integrity of Caco-2 Monolayers.Frontiers in medicine · 2020Article
- Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride.JGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Melatonin and Hippo Pathway: Is There Existing Cross-Talk?International journal of molecular sciences · 2017Article
- Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats.International journal of molecular sciences · 2016Article
- Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata.Mycotoxin research · 2016Article
- Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats.Journal of physiology and biochemistry · 2014Article
- Impact of light/dark cycle patterns on oxidative stress in an adriamycin-induced nephropathy model in rats.PloS one · 2014Article
- Protective effect of N-acetylserotonin against acute hepatic ischemia-reperfusion injury in mice.International journal of molecular sciences · 2013Article
- Fructose as a key player in the development of fatty liver disease.World journal of gastroenterology · 2013Review
- Melatonin levels in serum and ascitic fluid of patients with hepatic encephalopathy.Gastroenterology research and practice · 2012Article
- Hepatic organ protection: from basic science to clinical practice.World journal of gastroenterology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo, and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis, hemorrhagic shock, ischemia/reperfusion, and in numerous models of toxic liver injury. Melatonin's influence on hepatic antioxidant enzymes and other potentially relevant pathways, such as nitric oxide signaling, hepatic cytokine and heat shock protein expression, are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection, this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.