ArticleAutism research : official journal of the International Society for Autism Research2010
Variants in several genomic regions associated with asperger disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
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- Case Report: A novelFrontiers in psychiatry · 2026Article
- From genes to networks: neurobiological bases of neurodiversity across common developmental disorders.Frontiers in neuroscience · 2026Review
- "CRISPR for Disabilities: How to Self-Regulate" or Something?Journal of bioethical inquiry · 2022Article
- Synaptic processes and immune-related pathways implicated in Tourette syndrome.Translational psychiatry · 2021Article
- Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.American journal of human genetics · 2020Article
- Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism.Molecular autism · 2017Article
- Bio-collections in autism research.Molecular autism · 2017Review
- In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders.Neural plasticity · 2016Review
- A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?Biological psychiatry · 2015Article
- 3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances.Molecular cytogenetics · 2015Article
- Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.PloS one · 2015Article
- Common EIF4E variants modulate risk for autism spectrum disorders in the high-functioning range.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Advances in Genetic Discovery and Implications for Counseling of Patients and Families with Autism Spectrum Disorders.Current genetic medicine reports · 2014Article
- Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review).Biomedical reports · 2014Article
- Evolutionary conservation in genes underlying human psychiatric disorders.Frontiers in human neuroscience · 2014Article
- Common variation contributes to the genetic architecture of social communication traits.Molecular autism · 2013Article
- AKAPs integrate genetic findings for autism spectrum disorders.Translational psychiatry · 2013Article
- Brief report: Asperger's syndrome and sibling birth order.Journal of autism and developmental disorders · 2013Article
- Clinical and laboratory data in a sample of Greek children with autism spectrum disorders.Journal of autism and developmental disorders · 2012Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Asperger disorder (ASP) is one of the autism spectrum disorders (ASD) and is differentiated from autism largely on the absence of clinically significant cognitive and language delays. Analysis of a homogenous subset of families with ASP may help to address the corresponding effect of genetic heterogeneity on identifying ASD genetic risk factors. To examine the hypothesis that common variation is important in ASD, we performed a genome-wide association study (GWAS) in 124 ASP families in a discovery data set and 110 ASP families in a validation data set. We prioritized the top 100 association results from both cohorts by employing a ranking strategy. Novel regions on 5q21.1 (P = 9.7 × 10(-7) ) and 15q22.1-q22.2 (P = 7.3 × 10(-6) ) were our most significant findings in the combined data set. Three chromosomal regions showing association, 3p14.2 (P = 3.6 × 10(-6) ), 3q25-26 (P = 6.0 × 10(-5) ) and 3p23 (P = 3.3 × 10(-4) ) overlapped linkage regions reported in Finnish ASP families, and eight association regions overlapped ASD linkage areas. Our findings suggest that ASP shares both ASD-related genetic risk factors, as well as has genetic risk factors unique to the ASP phenotype.
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Registered trials
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