ArticleEuropean journal of immunology2011
Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease.
Article in European journal of immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Global, regional, and national burden of premenopausal and postmenopausal malignant melanoma from 1990 to 2021: a comprehensive cross-sectional analysis.American journal of cancer research · 2025Article
- Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis.Scientific reports · 2019Article
- Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis.Brain : a journal of neurology · 2018Article
- Ratio of Circulating Estrogen Receptors Beta and Alpha (ERβ/ERα) Indicates Endoscopic Activity in Patients with Crohn's Disease.Digestive diseases and sciences · 2017Article
- Consistent induction of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice for the longitudinal study of pathology and repair.Journal of neuroscience methods · 2017Article
- Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis.Journal of neuroimmunology · 2017Article
- The importance of studying sex differences in disease: The example of multiple sclerosis.Journal of neuroscience research · 2017Review
- Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function.Frontiers in immunology · 2017Review
- Effect of ovarian hormones on maturation of dendritic cells from peripheral blood monocytes in dogs.The Journal of veterinary medical science · 2015Article
- Estrogen receptors regulate innate immune cells and signaling pathways.Cellular immunology · 2015Review
- Role of the immunogenic and tolerogenic subsets of dendritic cells in multiple sclerosis.Mediators of inflammation · 2015Review
- FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases.Frontiers in immunology · 2015Review
- Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model.Journal of neuroscience research · 2013Article
- Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Estrogen effects in allergy and asthma.Current opinion in allergy and clinical immunology · 2013Review
- Therapeutic testosterone administration preserves excitatory synaptic transmission in the hippocampus during autoimmune demyelinating disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity.Hormones and behavior · 2012Review
- Sex-related factors in multiple sclerosis susceptibility and progression.Nature reviews. Neurology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Estrogens act upon nuclear estrogen receptors (ER) to ameliorate cell-mediated autoimmune disease. As most immunomodulatory effects of estrogens in EAE have been attributed to the function of ER-α, we previously demonstrated that ER-β ligand treatment reduced disease severity without affecting peripheral cytokine production or levels of CNS inflammation, suggesting a direct neuroprotective effect; however, the effect of ER-β treatment on the function of immune cells within the target organ remained unknown. Here, we used adoptive transfer studies to show that ER-β ligand treatment was protective in the effector, but not the induction phase of EAE, as shown by decreased clinical disease severity with the preservation of axons and myelin in spinal cords. The analysis of the immune cell infiltrates in the CNS revealed that while ER-β ligand treatment did not reduce overall levels of CNS inflammation, there was a decrease in the DC percentage, and these CNS DC had decreased TNF-α production. Finally, experiments using DC deficient in ER-β revealed that the expression of ER-β on DC was essential for protective effects of ER-β ligand treatment in EAE. Our results demonstrate for the first time an effect of ER-β ligand treatment in vivo on DC in the target organ of a prototypic cell-mediated autoimmune disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.