Evidence map›Paper›PMID 21181960›Full record

ArticleNeurourology and urodynamics2011

Mixed incontinence: comparing definitions in non-surgical patients.

Linda Brubaker, Emily S Lukacz, Kathryn Burgio, Philippe Zimmern, Peggy Norton, Wendy Leng, Harry Johnson, Stephen Kraus, Anne Stoddard

Registry-linked trialAbstract read
In one paragraph

Article in Neurourology and urodynamics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00090584 (Behavior Enhances Drug Reduction of Incontinence), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00090584 nacompletednot on this map

Behavior Enhances Drug Reduction of Incontinence

TypeinterventionalSponsorCarelon ResearchRan2004 to 2006Enrolled307ConditionsUrinary Incontinence (UI)ArmsTolterodine, Behavioral training
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Bladder training for treating overactive bladder in adults.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Observational
  7. Investigative and clinical urology · 2019
    Article
  8. Article
  9. Efficacy of mace (Arils ofIntegrative medicine research · 2018
    Article
  10. Article
  11. Clinical epidemiological insights into urinary incontinence.International urogynecology journal · 2017
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Linda BrubakerDepartments of Obstetrics & Gynecology and Urology, Loyola University, Chicago, Illinois 60153, USA. lbrubaker@lumc.edu
Emily S Lukacz
Kathryn Burgio
Philippe Zimmern
Peggy Norton
Wendy Leng
Harry Johnson
Stephen Kraus
Anne Stoddard

Funding

Urinary Incontinence Treatment Network: DCCU01DK058229 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI TENNSTEDT, SHARON L · 2000 to 2012
$16.1M
UAB Continence Treatment Center U01DK060380 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RICHTER, HOLLY E · 2001 to 2009
$3.9M
Urinary Incontinence Treatment NetworkU01DK058225 · NIDDK · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ZYCZYNSKI, HALINA M · 2000 to 2009
$3.8M
UCSD INCONTINENCE TREATMENT CENTERU01DK060401 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALBO, MICHAEL · 2001 to 2010
$3.6M
Continuation of the Urinary Incontinence Treatment Network (UITN)U01DK060379 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA · 2001 to 2009
$3.6M
UTAH URINARY INCONTINENCE TREATMENT NETWORK (UUITN)U01DK060393 · NIDDK · UNIVERSITY OF UTAH · PI NORTON, PEGGY A · 2001 to 2009
$3.4M
Urinary Incontinence Treatment NetworkU01DK058231 · NIDDK · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI SIRLS, LARRY T · 2000 to 2009
$3.3M
Urinary Incontinence Treatment Network (UITN)U01DK060397 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI CHAI, TOBY C · 2001 to 2010
$2.7M
Urinary Incontinence Treatment NetworkU01DK060395 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZIMMERN, PHILIPPE E · 2001 to 2009
$2.4M
The Urinary Incontinence Treatment NetworkU01DK058234 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KRAUS, STEPHEN R · 2000 to 2009
$2.3M
NIDDK NIH HHS U01 DK058225NIDDK NIH HHS U01 DK058229NIDDK NIH HHS U01 DK058231NIDDK NIH HHS U01 DK058234NIDDK NIH HHS U01 DK060379NIDDK NIH HHS U01 DK060380NIDDK NIH HHS U01 DK060393NIDDK NIH HHS U01 DK060395NIDDK NIH HHS U01 DK060397NIDDK NIH HHS U01 DK060401NIDDK NIH HHS U01 DK58225NIDDK NIH HHS U01 DK58229NIDDK NIH HHS U01 DK58231NIDDK NIH HHS U01 DK58234NIDDK NIH HHS U01 DK60379NIDDK NIH HHS U01 DK60380NIDDK NIH HHS U01 DK60393NIDDK NIH HHS U01 DK60395NIDDK NIH HHS U01 DK60397NIDDK NIH HHS U01 DK60401
6 · The paper itself

Abstract

purposeWe aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations.

methodsA secondary analysis of women with urge incontinence or urge predominant MUI enrolled in the Urinary Incontinence Treatment Network BE-DRI randomized clinical trial was performed. Subjects were characterized at baseline for urinary incontinence severity and incontinence subtype (stress or urge) using the Medical, Epidemiologic, and Social Aspects of Aging (MESA) questionnaire, the Urogenital Distress Inventory, and a 7-day urinary diary. Various different definitions of MUI, ranging from low to high threshold, were created using a combination of these baseline incontinence measures. Prevalence of MUI based on each definition was described and compared to treatment response. Logistic regression analysis was used to estimate the association between the study outcomes and the different definitions of MUI.

resultsThe 307 participants in the BE-DRI study had a mean age of 56.9 (± 13.9) years with a mean total MESA score of 21.7 (± 8.9) and a mean total UDI score of 120.5 (± 49.6). The proportion of women diagnosed with MUI varied significantly by definition ranging from 63.5% to 96.4%. Low threshold symptom-based definitions resulted in nearly universal diagnosis of MUI. No strict cut-off value for these baseline measures was identified to predict clinical outcomes.

conclusionsCurrent MUI definitions do not adequately categorize clinically relevant UI subgroups. For research purposes we believe it necessary to describe the severity of each incontinence subtype separately in subjects with MUI.

Indexed as

Terminology as TopicAgedBehavior TherapyBenzhydryl CompoundsCresolsExercise TherapyFemaleHumansLogistic ModelsMiddle AgedSurveys and QuestionnairesTreatment OutcomeUrinary IncontinenceUrinary Incontinence, StressUrinary Incontinence, UrgeUrodynamicsBenzhydryl CompoundsCresols

Identifiers

PMID21181960
PMCPMC3682677

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.