ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Identification and expression patterns of members of the protease-activated receptor (PAR) gene family during zebrafish development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.PLoS biology · 2025Article
- Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects.PLoS genetics · 2023Article
- A novel insight on SARS-CoV-2 S-derived fragments in the control of the host immunity.Scientific reports · 2023Article
- CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish.Developmental biology · 2022Article
- Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish.iScience · 2021Article
- Article
- Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia.The Journal of cell biology · 2018Article
- Gβ1 is required for neutrophil migration in zebrafish.Developmental biology · 2017Article
- Evolution of the protease-activated receptor family in vertebrates.International journal of molecular medicine · 2016Article
- Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium.Developmental biology · 2014Article
- Developmental role of zebrafish protease-activated receptor 1 (PAR1) in the cardio-vascular system.PloS one · 2012Article
- High resolution imaging of vascular function in zebrafish.PloS one · 2012Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Protease-activated receptors (PARs) play critical roles in hemostasis in vertebrates including zebrafish. However, the zebrafish gene classification appears to be complex, and the expression patterns of par genes are not established. Based on analyses of genomic organization, phylogenetics, protein primary structure, and protein internalization, we report the identification of four zebrafish PARs: par1, par2a, par2b, and par3. This classification differs from one reported previously. We also show that these genes have distinct spatiotemporal expression profiles in embryos and larvae, with par1, par2a, and par2b expressed maternally and ubiquitously during gastrula stages and their expression patterns refined at later stages, and par3 expressed only in 3-day-old larvae. Notably, the expression patterns of zebrafish par1 and par2b resemble those of their mammalian counterparts, suggesting that receptor function is conserved among vertebrates. This conservation is supported by our findings that Par1 and Par2b are internalized following exposure to thrombin and trypsin, respectively.
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Registered trials
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