ArticleJournal of medical virology2011
A novel real-time PCR system for simultaneous detection of human viruses in clinical samples from patients with uncertain diagnoses.
Article in Journal of medical virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
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- Practical norms in emerging infectious disease control: lessons for transnational collaboration from a suspected newly emerging zoonosis outbreak in Ghana.BMJ global health · 2025Article
- Varicella Zoster Virus Encephalitis with Advanced Human Immunodeficiency Virus Disease Diagnosed by Brain Biopsy.Internal medicine (Tokyo, Japan) · 2025Article
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- Case series: successful salvage from refractory cardiogenic shock caused by COVID-19-associated myocardial injury with temporary ventricular assist devices.European heart journal. Case reports · 2024Article
- Ineffective responses to unlikely outbreaks: Hypothesis building in newly-emerging infectious disease outbreaks.Medical anthropology quarterly · 2024Article
- Immune Checkpoint Inhibitors-Related Myocarditis: A Review of Reported Clinical Cases.Diagnostics (Basel, Switzerland) · 2023Review
- An autopsy case of fulminant myocarditis after severe acute respiratory syndrome coronavirus 2 vaccine inoculation.Pathology international · 2022Article
- Fulminant myocarditis after the first dose of mRNA-1273 vaccination in a patient with previous COVID-19: a case report.European heart journal. Case reports · 2022Article
- Myocarditis after COVID-19 mRNA vaccination in three young adult males: Significance of biopsy in vaccine-associated myocarditis.Pathology international · 2022Article
- Pathological findings of clinically suspected myocarditis temporally associated with COVID-19 vaccination.European journal of heart failure · 2022Article
- An atypical case of Kawasaki disease with severe pneumonia in a neonate.BMC pediatrics · 2022Article
- A fatal case of acute encephalopathy in a child due to coxsackievirus A2 infection: a case report.BMC infectious diseases · 2021Article
- Year-Round, Routine Testing of Multiple Body Site Specimens for Human Parechovirus in Young Febrile Infants.The Journal of pediatrics · 2021Article
- A case of acute liver failure with echovirus infection diagnosed by a multi-virus real-time PCR system.IDCases · 2021Article
- Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes.Signal transduction and targeted therapy · 2020Review
- Disseminated cortical and subcortical lesions in neonatal enterovirus 71 encephalitis.Journal of neurovirology · 2020Article
- Immune Checkpoint Inhibitor-Associated Cardiotoxicity: Current Understanding on Its Mechanism, Diagnosis and Management.Frontiers in pharmacology · 2019Review
- Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin.Pediatric pulmonology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel simultaneous detection system for human viruses was developed using a real-time polymerase chain reaction (PCR) system to identify causes of infection in clinical samples from patients with uncertain diagnoses. This system, designated as the "multivirus real-time PCR," has the potential to detect 163 human viruses (47 DNA viruses and 116 RNA viruses) in a 96-well plate simultaneously. The specificity and sensitivity of each probe-primer set were confirmed with cells or tissues infected with specific viruses. The multivirus real-time PCR system showed profiles of virus infection in 20 autopsies of acquired immunodeficiency syndrome patients, and detected frequently TT virus, cytomegalovirus, human herpesvirus 6, and Epstein-Barr virus in various organs; however, RNA viruses were detected rarely except for human immunodeficiency virus-1. Pathology samples from 40 patients with uncertain diagnoses were examined, including cases of encephalitis, hepatitis, and myocarditis. Herpes simplex virus 1, human herpesvirus 6, and parechovirus 3 were identified as causes of diseases in four cases of encephalitis, while no viruses were identified in other cases as causing disease. This multivirus real-time PCR system can be useful for detecting virus in specimens from patients with uncertain diagnoses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.