ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
Wide-beam reconstruction half-time SPECT improves diagnostic certainty and preserves normalcy and accuracy: a quantitative perfusion analysis.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Standardized Uptake Value Using Thyroid Quantitative SPECT/CT for the Diagnosis and Evaluation of Graves' Disease: A Prospective Multicenter Study.BioMed research international · 2019Trial
- Quantitative assessment of graves' ophthalmopathy activity usingEJNMMI research · 2026Article
- Quantitative analysis ofEJNMMI physics · 2023Article
- Technical note: Partitioning of gated single photon emission computed tomography raw data for protocols optimization.Journal of applied clinical medical physics · 2022Article
- The Importance of Time-of-Flight Reconstruction and Point Spread Modeling in the Measurement of Myocardial Blood Flow Parameters.Current cardiology reports · 2021Review
- Low-dose stress-only myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Contemporary Cardiac SPECT Imaging-Innovations and Best Practices: An Information Statement from the American Society of Nuclear Cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Advances in image reconstruction software in nuclear cardiology: Is all that glitters gold?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Taking the perfect nuclear image: quality control, acquisition, and processing techniques for cardiac SPECT, PET, and hybrid imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Recent trends in nuclear cardiology practice.Chonnam medical journal · 2013Review
- Recent advances in cardiac SPECT instrumentation and system design.Current cardiology reports · 2013Review
- Myocardial perfusion imaging with a solid-state camera: simulation of a very low dose imaging protocol.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- Proof of concept for low-dose molecular breast imaging with a dual-head CZT gamma camera. Part I. Evaluation in phantoms.Medical physics · 2012Article
- Advances in SPECT camera software and hardware: currently available and new on the horizon.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
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6 authors.
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Abstract
backgroundFiltered back-projection (FBP) has been a standard in SPECT imaging. Newer iterative reconstruction algorithms have been shown to improve image quality and shorten acquisition time by taking into account statistical nature of raw data and using resolution recovery (RR). Wide-beam reconstruction (WBR) is an iterative algorithm with RR and adaptive noise control. We prospectively investigated outcome of WBR half-time SPECT on diagnostic certainty, accuracy and normalcy by quantitative perfusion analysis in comparison to full-time FBP images.
methods434 patients underwent rest (201)Tl/stress (99m)Tc-sestamibi full-time (20 s/stop, FBP) followed by a half-time (10 s/stop, WBR) SPECT. 34 patients underwent an angiogram within 90 days of SPECT. Diagnostic certainty was based on summed stress scores (SSS, 5-point/17 segments): normal if SSS ≤ 1, equivocal if SSS = 2-3, and abnormal if SSS ≥ 4. Perfusion defects were normalized to a percent of total myocardium, and expressed as %LV = defect SSS/maximal SSS × 100% with maximal SSS of 28 for left anterior descending (LAD), and of 20 for right coronary (RCA) and left circumflex (LCX). Change in %LV (Δ%LV = %LV FBP - %LV WBR) was evaluated for diagnostically discordant versus concordant scans.
resultsSSS and %LV demonstrated very good correlation. There were significantly fewer equivocal scans with WBR (38 vs 151 FBP, P < .0001). Most discordant scans were equivocal FBP SPECT becoming normal with WBR (123/151). Δ%LV(LAD) for discordant studies was greater for women (5.4% ± 4.2%, P < .001), while Δ%LV(RCA,LCX) (4.4% ± 5.1%, P < .001; 1.2% ± 5.0%, P = .04) were greater for men. Normalcy rate was 91.4% for FBP and WBR with more definitely normal WBR studies (84.5% vs 43.9% for FBP, P < .0001). There were no differences in sensitivity (FBP 84.2%, WBR 81.6%), specificity (FBP 54.6%, WBR 63.6%), and accuracy (FBP, WBR 77.6%).
conclusionQuantitative perfusion analysis suggests that adaptive noise control with WBR improves uniformity of myocardium comparing to FBP techniques, and results in improved diagnostic certainty while preserving normalcy and accuracy.
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