ArticleMolecular biology reports2011
Polymorphisms of caprine GDF9 gene and their association with litter size in Jining Grey goats.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Effect ofAnimals : an open access journal from MDPI · 2025Article
- Potential Candidate Genes Associated with Litter Size in Goats: A Review.Animals : an open access journal from MDPI · 2025Review
- The relationship between G1 (c.260 G>A) and G4 (c.721 G>A) polymorphisms in the GDF9 gene and the litter size of sheep: A meta-analysis study.Journal of advanced veterinary and animal research · 2023Article
- Polymorphism and expression ofArchives animal breeding · 2023Article
- Analysis of the Association of Two SNPs in the Promoter Regions of theAnimals : an open access journal from MDPI · 2022Article
- Development and Application of a High-Resolution Melting Analysis with Unlabeled Probes for the Screening of Short-Tailed SheepAnimals : an open access journal from MDPI · 2022Article
- Genome-wide association study reveals novel candidate genes for litter size in Markhoz goats.Frontiers in veterinary science · 2022Article
- Detection of Novel Variations Related to Litter Size inAnimals : an open access journal from MDPI · 2021Article
- A study on mutation points of GDF9 gene and their association with prolificacy in Egyptian small ruminants.Journal, genetic engineering & biotechnology · 2021Article
- Polymorphism Detection ofAnimals : an open access journal from MDPI · 2021Article
- Two Novel Rare Strongly Linked Missense SNPs (P27R and A85G) Within theFrontiers in veterinary science · 2020Article
- Genetic Effects of Single Nucleotide Polymorphisms in the GoatAnimals : an open access journal from MDPI · 2019Review
- A Mini-Atlas of Gene Expression for the Domestic Goat (Frontiers in genetics · 2019Article
- Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits.BioMed research international · 2018Article
- Allelic and genotypic frequencies in polymorphic Booroola fecundity gene and their association with multiple birth and postnatal growth in Chhotanagpuri sheep.Veterinary world · 2016Article
- Prolificacy and Its Relationship with Age, Body Weight, Parity, Previous Litter Size and Body Linear Type Traits in Meat-type Goats.Asian-Australasian journal of animal sciences · 2014Article
- Analysis of the polymorphisms in the caprine Gli3 gene and their associations with production traits in goats.Molecular biology reports · 2013Article
- Molecular characterization of growth differentiation factor 9 and its spatio-temporal expression pattern in gibel carp (Carassius auratus gibelio).Molecular biology reports · 2012Article
- Bovine GDF10 gene polymorphism analysis and its association with body measurement traits in Chinese indigenous cattle.Molecular biology reports · 2012Article
- Polymorphism of GDF9 gene and its association with litter size in goats.Veterinary research communications · 2011Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exons 1, 2 and flanking region of growth differentiation factor 9 (GDF9) gene in five randomly selected does of Jining Grey, Boer and Liaoning Cashmere goats were amplified and analyzed. Thirteen nucleotide differences were identified in GDF9 gene between sheep (AF078545) and goats. Four SNPs (G3288A in intron 1, G423A, A959C [Gln320Pro] and G1189A [Val397Ile] in exon 2) were detected in four goat breeds with different prolificacy, in which G3288A was a new SNP in goats. The results showed that loci 3288, 423 and 1189 in Boer goats, loci 3288 and 423 in Guizhou White goats, loci 423 and 1189 in Liaoning Cashmere goats were all in complete linkage disequilibrium (D' = 1, r (2) = 1), respectively. In moderate (Boer goat) and low prolificacy (Liaoning Cashmere goat) breeds, linkage analysis indicated that there were more fervent linkage disequilibrium among loci 3288, 423 and 1189 than high prolificacy (Jining Grey and Guizhou White goats) breeds. For the 959 locus, the genotype distribution showed obvious difference between high prolificacy breeds and moderate or low prolificacy breeds (P < 0.05 or P < 0.01). The Jining Grey goat does with genotype CC or AC had 0.81 (P < 0.01) or 0.63 (P < 0.01) kids more than those with genotype AA, respectively. The present study preliminarily showed an association between allele C at 959 locus of GDF9 gene and high litter size in Jining Grey goats. These results provide further evidence that the GDF9 gene may be significantly correlated with high prolificacy in goats.
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