ReviewClinical reviews in allergy & immunology2011
Viruses and cytotoxic T lymphocytes in type 1 diabetes.
Review in Clinical reviews in allergy & immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets.Nature communications · 2025Article
- Analysis of characteristics of peripheral blood lymphocytes in endometrial carcinoma: a single-center study based on five-year clinical data.BMC cancer · 2024Article
- Charting Peptide Shared Sequences Between 'Diabetes-Viruses' and Human Pancreatic Proteins, Their Structural and Autoimmune Implications.Bioinformatics and biology insights · 2024Article
- Variable frequencies of peripheral T-lymphocyte subsets in the diabetes spectrum from type 1 diabetes through latent autoimmune diabetes in adults (LADA) to type 2 diabetes.Frontiers in immunology · 2022Article
- Jigsaw falling into place: A review and perspective of lymphoid tissue CD8+ T cells and control of HIV.Molecular immunology · 2020Review
- β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.Diabetes · 2015Article
- RNase L contributes to experimentally induced type 1 diabetes onset in mice.The Journal of endocrinology · 2014Article
- Potential viral pathogenic mechanism in human type 1 diabetes.Diabetologia · 2014Review
- The environment and the origins of islet autoimmunity and Type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2013Review
- Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma.Clinical and experimental immunology · 2012Review
- Autoimmunity and environment: am I at risk?Clinical reviews in allergy & immunology · 2012Review
- Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.PLoS pathogens · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Histopathological studies on pancreas tissues from individuals with recent-onset type 1 diabetes (T1D) consistently find that CD8 T cells substantially contribute to the formation of islet lesions. CD8 T cells reactive against islet-associated antigens can also be found in blood samples from T1D patients. Mechanistic studies on the pathogenic role of this T cell subset have mostly focused on two animal models, i.e., the non-obese diabetic mouse and the virally induced rat insulin promoter-lymphocytic choriomeningitis virus model. Data were obtained in support of a role for viral infection in expanding a population of diabetogenic cytotoxic T lymphocytes. In view of the theorized association of viral infection with initiation of islet autoimmunity and progression to clinically overt disease, CD8 T cells thus represent an attractive target for immunotherapy. We will review here arguments in favor of a pivotal role for CD8 T cells in driving T1D development and speculate on etiologic agents that may provoke their aberrant activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.