ArticleParasitology research2011
Serodiagnosis of experimental sparganum infections of mice and human sparganosis by ELISA using ES antigens of Spirometra mansoni spargana.
Article in Parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The global prevalence of Spirometra parasites in snakes, frogs, dogs, and cats: A systematic review and meta-analysis.Veterinary medicine and science · 2022Pooled it
- The Development and Evaluation of a Loop-Mediated Isothermal Amplification (LAMP) Method for the Detection ofVeterinary sciences · 2026Article
- Development of an Indirect ELISA and a Microsphere Detection Test Strip for the Detection of Spirometra mansoni.Transboundary and emerging diseases · 2026Article
- MRI Characteristics of Intraspinal Sparganosis: A Case ReportCurrent medical imaging · 2026Article
- Development of an immunochromatographic test for serodiagnosis of human sparganosis.Parasitology research · 2025Article
- The serum IgG antibody level as a biomarker for clinical outcome in patients with cerebral sparganosis after treatment.Frontiers in immunology · 2023Article
- Surgical treatment of a patient with live intracranial sparganosis for 17 years.BMC infectious diseases · 2022Article
- A Human Case of Lumbosacral Canal Sparganosis in China.The Korean journal of parasitology · 2021Article
- Proteomic and Immunological Identification of Diagnostic Antigens from Spirometra erinaceieuropaei Plerocercoid.The Korean journal of parasitology · 2021Article
- Sparganosis (Veterinary world · 2021Article
- Molecular characterization of a Trichinella spiralis elastase-1 and its potential as a diagnostic antigen for trichinellosis.Parasites & vectors · 2020Article
- Case Report: Human Subcutaneous Sparganosis in a Thai Migrant.The American journal of tropical medicine and hygiene · 2019Article
- First report of sparganosis manifested by pleuritis and decreased peripheral blood eosinophils in Jiangsu province, China.Parasitology research · 2019Article
- Characterization of a Trichinella spiralis putative serine protease. Study of its potential as sero-diagnostic tool.PLoS neglected tropical diseases · 2018Article
- Significance of Serology by Multi-Antigen ELISA for Tissue Helminthiases in Korea.Journal of Korean medical science · 2017Article
- A neglected risk for sparganosis: eating live tadpoles in central China.Infectious diseases of poverty · 2017Article
- Molecular Identification of Spirometra erinaceieuropaei Tapeworm in Cases of Human Sparganosis, Hong Kong.Emerging infectious diseases · 2017Article
- New diagnostic antigens for early trichinellosis: the excretory-secretory antigens of Trichinella spiralis intestinal infective larvae.Parasitology research · 2015Article
- Occurrence of human sparganosis in Kerala.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Molecular cloning and characterization of a Spirometra erinacei casein kinase I.Parasitology research · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a study of serodiagnosis of experimental sparganum infections of mice and human sparganosis by enzyme-linked immunosorbent assay (ELISA) using excretory-secretory (ES) antigens of Spirometra mansoni spargana and compared the sensitivity and specificity of crude and ES antigens for detecting the specific anti-sparganum IgG antibodies. By crude antigen ELISA and ES antigen ELISA, anti-sparganum IgG was detected in all of 30 serum samples of the infected mice; no cross-reactions were observed in serum samples of the mice infected with Trichinella spiralis, Schistosoma japanicum, Toxoplasma gondii, and normal mice. Anti-sparganum IgG was detected by ES antigen ELISA in sera of mice infected with one, two, four, six, and eight spargana at 3 weeks post-infection (wpi), with a detection rate of 100%, and lasted to 18 wpi when the experiment was ended. The difference in anti-sparganum antibody levels among five groups of the infected mice was statistically significant (F=245.296, p<0.05); the antibody levels were correlated with infecting doses of spargana (r=0.323, p<0.05). The sensitivity of both ELISA in detecting the serum samples of patients with sparganosis was 100% (20/20), but 96.72% (59/61) of specificity of ES antigen ELISA in detecting serum samples of patients with cysticercosis, echinococcosis, paragonimiosis, clonorchiosis, and schistosomiasis, and healthy persons was significantly greater than 72.13% (44/61) of crude antigen ELISA (χ (2) = 14.027, p<0.05). Our finding indicates that ELISA using ES antigens of S. mansoni spargana may be applied to the specific early serodiagnosis of sparganosis.
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