ArticlePsychopharmacology2011
Antidepressant response to chronic citalopram treatment in eight inbred mouse strains.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Variation in cocaine responses across genetically diverse mouse strains.Psychopharmacology · 2026Article
- Comparative assessment of antidepressant-related behaviors of citalopram, crocin, and their combination in non-acute restraint stress and acute restraint stress mice.IBRO neuroscience reports · 2025Article
- Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide.International journal of molecular sciences · 2024Article
- Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion.Stem cell research · 2019Article
- Increased depression-related behavior during the postpartum period in inbred BALB/c and C57BL/6 strains.Molecular brain · 2019Article
- Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior.Translational psychiatry · 2019Article
- Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2.Neuropsychopharmacology reports · 2019Article
- Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor.Journal of medicinal chemistry · 2019Article
- Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression.Frontiers in neuroscience · 2019Article
- Identification of a novel, fast-acting GABAergic antidepressant.Molecular psychiatry · 2018Article
- Identifying fast-onset antidepressants using rodent models.Molecular psychiatry · 2017Review
- Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains.BMC genomics · 2015Article
- Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice.Psychopharmacology · 2015Article
- Article
- Facilitation of serotonin signaling by SSRIs is attenuated by social isolation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Serotonin 2C receptor antagonists induce fast-onset antidepressant effects.Molecular psychiatry · 2014Article
- Gestational environment programs adult depression-like behavior through methylation of the calcitonin gene-related peptide gene.Molecular psychiatry · 2013Article
- Sex differences in stress-induced social withdrawal: role of brain derived neurotrophic factor in the bed nucleus of the stria terminalis.Frontiers in behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe antidepressant response exhibits a characteristic delay. BALB/cJ mice respond to chronic, but not subchronic, treatment with selective serotonin reuptake inhibitors (SSRIs), providing a model of antidepressant onset. Identification of other mouse strains exhibiting this phenotype will provide additional tools for studying mechanisms of the antidepressant response.
objectivesWe aimed to identify inbred mouse strains that respond to chronic, but not subchronic, SSRI treatment in the forced swim test (FST). We also assessed whether response correlated with genotype at the functional C1473G polymorphism in tryptophan hydroxylase-2 (Tph2).
methodsBALB/cJ, three closely related strains (BALB/cByJ, SEA/GnJ, A/J), and four distantly related strains (C57BL/6J, C57BL/10J, CAST/EiJ, SM/J) received the SSRI citalopram (0-30 mg/kg/day in drinking water) for ~4 weeks and were assessed for locomotion and FST behavior. Citalopram-responsive strains were assessed identically following ~1 week of treatment. C1473G genotypes were determined.
resultsBALB/cJ and related strains carried the 1473G allele and responded to chronic citalopram treatment in the FST. BALB/cJ, BALB/cByJ, and SEA/GnJ mice showed either no response or an attenuated response to subchronic treatment. Distantly related strains carried the 1473C allele and showed no response to citalopram. No relationship was found between the antidepressant response and baseline immobility or locomotion.
conclusionsBALB/cJ and related strains exhibit an antidepressant response to chronic SSRI treatment that emerges over time and is likely a heritable trait. This antidepressant response is associated with carrying the 1473G allele in Tph2. In conclusion, BALB/cJ and related strains provide valuable models for studying the therapeutic mechanisms of SSRIs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.