ArticleThe EMBO journal1990
Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 220 citations in OpenAlex.
- Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells.Haematologica · 2020Article
- Soluble and membrane-bound interleukin (IL)-15 Rα/IL-15 complexes mediate proliferation of high-avidity central memory CD8Clinical and experimental immunology · 2016Article
- MiR-7-1 potentiated estrogen receptor agonists for functional neuroprotection in VSC4.1 motoneurons.Neuroscience · 2014Article
- Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.The Journal of biological chemistry · 2011Article
- Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation.International journal of oncology · 2010Article
- Calpain-1 cleaves and activates caspase-7.The Journal of biological chemistry · 2009Article
- Apoptosis and cancer: the genesis of a research field.Nature reviews. Cancer · 2009Review
- Apoptosis in the initiation, modulation and termination of the corneal wound healing response.Experimental eye research · 2007Review
- Article
- MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival.The Journal of biological chemistry · 2005Article
- Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin's Lymphoma Cells.Journal of clinical immunology · 2004Article
- Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24.Genes and immunity · 2004Article
- Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.Molecular and cellular biology · 2003Article
- Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor.Molecular and cellular biology · 2003Article
- Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency.Molecular and cellular biology · 2001Article
- Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction.The Biochemical journal · 2001Article
- Kinases: positive and negative regulators of apoptosis.Leukemia · 2000Review
- Involvement of p53 and interleukin 3 in the up-regulation of CD95 (APO-1/Fas) by X-ray irradiation.Oncogene · 2000Article
- Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor.Molecular and cellular biology · 2000Article
- Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An immortalized interleukin-3 (IL-3)-dependent progenitor cell line, BAF-3, undergoes programmed cell death (apoptosis) when deprived of IL-3. This program is characterized by an early degradation of DNA into oligonucleosome-length fragments that precedes by several hours the loss of cell viability. In the absence of IL-3, DNA fragmentation and cell death can be prevented by the calcium ionophores A23187 (1 microM) and ionomycin (0.5 microM). This addition of calcium ionophore maintains cell viability while reversibly arresting the cell cycle. Apoptosis by growth factor deprivation is also a mechanism of cell elimination in bone marrow cells removed from the stromal micro-environment, as DNA fragmentation and cell death was shown to take place in primary cultures of IL-3-responsive bone marrow cells after IL-3 removal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.