ArticleTherapeutic advances in neurological disorders2009
Depression in epilepsy: mechanisms and therapeutic approach.
Article in Therapeutic advances in neurological disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Antidepressants for people with epilepsy and depression.The Cochrane database of systematic reviews · 2021Pooled it
- Depression among epileptic patients and its association with drug therapy in sub-Saharan Africa: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Adverse events of placebo-treated, drug-resistant, focal epileptic patients in randomized controlled trials: a systematic review.Journal of neurology · 2015Pooled it
- Antidepressants for people with epilepsy and depression.The Cochrane database of systematic reviews · 2014Pooled it
- Engineering a chitosan-based nanoemulsion for non-invasive CNS-targeting approach: dual neuroprotection against epileptic and depressive disorders.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Occurrence and clinical correlates of depressive symptoms in adults with epilepsy: A study in Georgia.Epilepsia open · 2026Article
- Prevalence and Predictors of Psychiatric Comorbidities in Adults with Epilepsy: A Cross-sectional Study from a Tertiary Care Centre.Annals of neurosciences · 2026Article
- Prevalence and factors associated with psychosis among adults with epilepsy at a tertiary hospital in Uganda, cross-sectional study.Epilepsy & behavior : E&B · 2024Article
- Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence.Neuropharmacology · 2023Review
- Depressive symptoms in patients with epilepsy and clinically associated features in a single tertiary center.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Commonalities for comorbidity: Overlapping features of the endocannabinoid system in depression and epilepsy.Frontiers in psychiatry · 2022Review
- Evaluation of Depression with Mixed Features and Bipolarity Screening in Patients with Epilepsy.Psychiatry and clinical psychopharmacology · 2021Article
- Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.Frontiers in human neuroscience · 2021Article
- High Rates of Genetic Diagnosis in Psychiatric Patients with and without Neurodevelopmental Disorders: Toward Improved Genetic Diagnosis in Psychiatric Populations.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?International journal of molecular sciences · 2018Article
- Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy.The Journal of international medical research · 2018Article
- The effects of herbal medicine on epilepsy.Oncotarget · 2017Review
- [Coexistent depressive and anxiety disorders in epilepsy and multiple sclerosis: a challenge to neuropsychiatric practice].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2014Review
- Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder?British journal of pharmacology · 2013Review
- [Psychiatric aspects of epileptic disorders].Der Nervenarzt · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with epilepsy, mood disorders represent a frequent psychiatric comorbidity but they often remain unrecognized and untreated. However, comorbid depression may have a major impact on the quality of life of patients with epilepsy, sometimes even more than the seizures. Among the potential neurobiological and psychosocial determinants, epilepsy-related variables (age at onset of seizures, temporal lobe epilepsy and frequency of seizures) and the antiepileptic drug treatment have been associated with depression. Nonetheless, data on treatment strategies are still limited with a lack of controlled trials on the use of antidepressant drugs. Moreover, the issue of psychotropic drug treatment of depression in epilepsy is interlinked with that of worsening seizures. This paper is aimed at discussing all these subjects in the light of current literature on the neurobiology of depression in epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.