ArticlePloS one2010
FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Does theFMR1 gene affect IVF success?Reproductive biomedicine online · 2019Pooled it
- The impact of FMR1 gene mutations on human reproduction and development: a systematic review.Journal of assisted reproduction and genetics · 2016Pooled it
- Article
- Prepregnancy Polycystic Ovary Syndrome as a Risk Factor of Subsequent Preterm Labor: A National Population-Based Cohort Study.International journal of environmental research and public health · 2022Article
- Predictive value of anti-Müllerian hormone on pregnancy outcomes in in-vitro fertilization/intracytoplasmic single sperm injection patients at different ages.Archives of gynecology and obstetrics · 2021Article
- Moxibustion improves ovarian function based on the regulation of the androgen balance.Experimental and therapeutic medicine · 2021Article
- The Risk of Subsequent Miscarriage in Pregnant Women with Prior Polycystic Ovarian Syndrome: A Nationwide Population-Based Study.International journal of environmental research and public health · 2021Article
- The association ofArchives of medical science : AMS · 2021Article
- Prepregnancy Endocrine, Autoimmune Disorders and the Risks of Gestational Hypertension-Preeclampsia in Primiparas: A Nationwide Population-Based Study in Taiwan.International journal of environmental research and public health · 2020Article
- FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve.Reproductive biology and endocrinology : RB&E · 2018Article
- Article
- Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study.Reproductive biology and endocrinology : RB&E · 2017Article
- Genetics of androgen metabolism in women with infertility and hypoandrogenism.Nature reviews. Endocrinology · 2015Review
- Prospectively assessing risk for premature ovarian senescence in young females: a new paradigm.Reproductive biology and endocrinology : RB&E · 2015Article
- FMR1 CGG allele length in Israeli BRCA1/BRCA2 mutation carriers and the general population display distinct distribution patterns.Genetics research · 2014Article
- Utilizing FMR1 gene mutations as predictors of treatment success in human in vitro fertilization.PloS one · 2014Article
- How the FMR1 gene became relevant to female fertility and reproductive medicine.Frontiers in genetics · 2014Article
- Article
- Endocrine autoimmune diseases and female infertility.Nature reviews. Endocrinology · 2014Review
- FMR1-dependent variability of ovarian aging patterns is already apparent in young oocyte donors.Reproductive biology and endocrinology : RB&E · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FMR1 gene partially appears to control ovarian reserve, with a specific ovarian sub-genotype statistically associated with a polycystic ovary (PCO)- like phenotype. Some forms of PCO have been associated with autoimmunity. We, therefore, investigated in multiple regression analyses associations of ovary-specific FMR1 genotypes with autoimmunity and pregnancy chances (with in vitro fertilization, IVF) in 339 consecutive infertile women (455 IVF cycles), 75 with PCO-like phenotype, adjusted for age, race/ethnicity, medication dosage and number of oocytes retrieved. Patients included 183 (54.0%) with normal (norm) and 156 (46%) with heterozygous (het) FMR1 genotypes; 133 (39.2%) demonstrated laboratory evidence of autoimmunity: 51.1% of het-norm/low, 38.3% of norm and 24.2% het-norm/high genotype and sub-genotypes demonstrated autoimmunity (p=0.003). Prevalence of autoimmunity increased further in PCO-like phenotype patients with het-norm/low genotype (83.3%), remained unchanged with norm (34.0%) and decreased in het-norm/high women (10.0%; P<0.0001). Pregnancy rates were significantly higher with norm (38.6%) than het-norm/low (22.2%, p=0.001). FMR1 sub-genotype het-norm/low is strongly associated with autoimmunity and decreased pregnancy chances in IVF, reaffirming the importance of the distal long arm of the X chromosome (FMR1 maps at Xq27.3) for autoimmunity, ovarian function and, likely, pregnancy chance with IVF.
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Registered trials
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